Effect of lignin-derived lignophenols on hepatic lipid metabolism in rats fed a high-fat diet

Environmental Toxicology and Pharmacology
Shin SatoShuzo Fujita

Abstract

The effect of lignin-derived lignophenols on lipid metabolism in the livers of rats fed a high-fat diet was investigated. Rats fed a diet providing 45% of energy from fat were divided into 2 groups, namely 0% and 0.5% lignophenols-containing diets. The controls were fed a diet providing 10% of energy from fat. Plasma blood parameters, protein expression of acetyl-CoA carboxylase (ACC) and sterol regulatory element-binding protein (SREBP)-1, and SREBP-1c mRNA expression in the livers were examined. The plasma triglyceride levels in the rats fed lignophenols-containing diets were decreased. SREBP-1c mRNA expression in the rats fed lignophenols-containing diets was significantly reduced compared with the rats fed high-fat diets, and phosphorylated ACC protein in the rats fed lignophenols-containing diets was significantly increased. Our results suggested that lignophenols suppress the expression of SREBP-1c mRNA and the phosphorylation of ACC in the liver, and may lead to a decrease in plasma triglyceride levels.

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Citations

Jun 8, 2017·International Journal of Molecular Sciences·Maria Pilar Vinardell, Montserrat Mitjans
Aug 11, 2020·International Journal of Biological Macromolecules·Cristiane Moutinho Lagos de MeloGeorge Jackson de Moraes Rocha
Jul 20, 2021·Advanced Drug Delivery Reviews·Zhejie ChenYitao Wang
Dec 29, 2018·Journal of Agricultural and Food Chemistry·Ghulam Shere RazaKarl-Heinz Herzig

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