Effect of lignocaine and pH on propofol-induced pain

British Journal of Anaesthesia
M ErikssonP Hartvig

Abstract

Propofol has the disadvantage of pain on injection. A higher partition of propofol in the aqueous phase of the preparation causes a higher incidence of pain on injection while addition of 1% lignocaine to propofol reduces pain. The low concentration of this local anaesthetic and the rapid pain relief observed indicates that mechanisms other than local anaesthesia are involved, that is change in pH. We performed a clinical study to investigate the influence of lignocaine and pH on pain during injection of 1% Diprivan. Ten parts of 1% Diprivan were mixed with one part of saline, 1% lignocaine or hydrochloric acid to achieve the same pH as that after addition of lignocaine. Diprivan 1% mixed with 1% lignocaine and with hydrochloric acid gave mean pain ratings (1-10) of 0.32 (SD 0.75) (n = 25) and 0.88 (1.30) (n = 24), respectively. These ratings were significantly lower than ratings after injection of a saline-Diprivan mixture (2.18 (2.06), n = 22). The pH of the 1% Diprivan formulation decreased after mixing with 1% lignocaine. The concentration of propofol in the aqueous phase was lower when 1% Diprivan was mixed with 1% lignocaine (0.376 g litre-1) or HCl (0.392 g litre-1) compared with 1% Diprivan and saline (0.476 g litre-1) ...Continue Reading

Citations

Jun 29, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hiroshi OhmizoHiroshi Iwama
Jul 27, 2001·Acta Anaesthesiologica Scandinavica·E LiljerothJ Akeson
Mar 5, 2003·The Clinical Journal of Pain·Prakash K Dubey, Sureshwar S Prasad
Aug 1, 2015·Journal of Maxillofacial and Oral Surgery·Amit S NirwanSaba Tiwari
Jul 7, 2011·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Marzieh-Beigom Khezri, Hamid Kayalha
Mar 11, 2016·Indian Journal of Anaesthesia·Gangur Basappa SumalathaParashuram R Jajee
Jul 20, 2010·International Journal of Pharmaceutics·Yun-Seok RheeEun-Seok Park
Feb 24, 2009·Journal of Clinical Anesthesia·James D Austin, Timothy J Parke
Feb 18, 2009·British Journal of Clinical Pharmacology·Ji-Yeon SimGyu-Jeong Noh
Dec 14, 2004·Journal of Clinical Anesthesia·Leyla IyilikciHülya Ellidokuz
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·T Graven-Nielsen
Jun 17, 2003·The Journal of Veterinary Medical Science·Tadashi SanoNobuo Sasaki
Feb 28, 2014·The Journal of International Medical Research·Yun-Hee KimChoon-Hak Lim
Jun 10, 2010·Korean journal of anesthesiology·Yong Ku HanHyung Gon Lee
Dec 4, 2015·Korean journal of anesthesiology·Nurcan KizilcikOzge Koner
Feb 19, 2016·The Cochrane Database of Systematic Reviews·Pramote EuasobhonPisake Lumbiganon
Nov 25, 2003·Anesthesia and Analgesia·Yoko MasakiToshiaki Nishikawa
Jul 11, 2006·European Journal of Anaesthesiology·B Bachmann-MennengaM Heesen
Jan 24, 2007·European Journal of Anaesthesiology·H AyoğluI Ozkoçak
Jun 24, 2000·European Journal of Anaesthesiology·J ShahJ Rangasami
May 4, 1999·European Journal of Anaesthesiology·M ErikssonP Hartvig
Jul 23, 2005·Anesthesia and Analgesia·Michiaki YamakageAkiyoshi Namiki
Mar 29, 2000·Anesthesia and Analgesia·P Picard, M R Tramèr
Mar 29, 2000·Anesthesia and Analgesia·Y MasakiT Nishikawa
Jul 18, 2019·European Journal of Pain : EJP·Line Bay SørensenThomas Graven-Nielsen
Jul 11, 1998·Anaesthesia·C H Tan, M K Onsiong
Jan 15, 2005·Anaesthesia and Intensive Care·M MohtaK Sandhu

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