Effect of Ligustrazine on liver injury after burn trauma

Burns : Journal of the International Society for Burn Injuries
Hong ZhengZhi-Wu Chen

Abstract

This study was designed to investigate the effect of Ligustrazine on burn-induced liver injury as well as the activation of nuclear factor kappaB (NF-kappaB) in severely burned rats. Sprague-Dawley rats were divided into three groups: (1) sham group, rats who underwent sham burn; (2) control group, rats given third-degree burns over 30% total body surface area (TBSA) and lactated Ringer solution for resuscitation; (3) Ligustrazine group, rats given burn and lactated Ringer's solution with Ligustrazine inside for resuscitation. Liver injury was assessed at 24 h post-burn by serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as liver wet/dry weight ratio. Liver myeloperoxidase (MPO) activity was also analyzed. Hepatic NF-kappaB activity was examined by electrophoretic mobility shift assay (EMSA). Burn results in hepatic dysfunction and increased hepatic NF-kappaB activity, elevated liver wet/dry ratio and hepatic MPO activity. Ligustrazine inhibited these changes and alleviated burn-mediated hepatic dysfunction. The data indicated that Ligustrazine has a protective effect on burn-induced liver injury and possible mechanism may be attributed to its inhibitory action on the activation of NF...Continue Reading

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Citations

Jun 12, 2013·Archives of Dermatological Research·Pornanong AramwitPornprom Muangman
Nov 5, 2013·Environmental Toxicology and Pharmacology·Hong ZhengFang Ni
Jan 22, 2011·Journal of Gastroenterology and Hepatology·Zhe ChenHong-Yi Zhu
Jan 12, 2008·The American Journal of Chinese Medicine·Liang XiongGang Feng
Jul 17, 2014·Cell Biochemistry and Biophysics·Xuan Xiu JiJian You Zhu
Jun 10, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Gurkan OzturkHamit Acemoglu
Jan 12, 2016·Expert Opinion on Drug Metabolism & Toxicology·Yan GuoWen Xie
Jul 9, 2013·The Journal of Surgical Research·Jin-quan WangYu-guo Chen
Jul 19, 2015·International Journal of Surgery·Hui ZhangYaoyao Bian
Mar 10, 2009·Toxicology and Applied Pharmacology·S AroraK M Paknikar
Oct 13, 2012·International Journal of Immunopathology and Pharmacology·G BekyarovaI Kotzev
Dec 12, 2020·The Journal of Trauma and Acute Care Surgery·Juan-Pablo IdrovoElizabeth J Kovacs

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