Effect of limonene and sobrerol on monocrotaline-induced lung alterations and pulmonary hypertension

International Archives of Allergy and Immunology
C TouvayP Braquet

Abstract

The effects of two monocyclic monoterpenes, limonene and sobrerol, known as inhibitors of farnesyltransferase activity, were studied on monocrotaline (MCT)-induced lung injury, pulmonary hypertension and right ventricular hypertrophy in male Wistar rats. After 14 days, pulmonary arterial pressure values and the right ventricle to left ventricle plus septum weight ratios, RV/(LV + S), were markedly increased in rats subcutaneously injected with MCT (60 mg/kg). Limonene and sobrerol, administered daily at the oral dose of 400 mg/rat, markedly decreased the MCT-induced alterations. After treatment for 21 days, limonene still prevented pulmonary hypertension and the increase in RV/(LV + S). Both monoterpenes also reduced the increase in pulmonary arterial media thickness, the development of interstitial fibrosis and the increase in the number of macrophages in intra-alveolar spaces and of lymphocytes around the pulmonary veins. The present data indicate that treatment of rats with inhibitors of farnesyltransferase, like limonene and sobrerol, regulate the development of pulmonary hypertension.

Citations

Mar 30, 2011·European Journal of Nutrition·Jesudoss Victor Antony SantiagoNamasivayam Nalini
Apr 11, 2017·Cardiovascular Research·Daphne Merkus, Ralph T Schermuly
Mar 30, 2020·Current Pharmaceutical Design·Hericalizandra SantanaMárcio Roberto
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Reda E GirgisRoger A Johns
Jan 24, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Eric Aian P SilvaMárcio R V Santos

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