Effect of lindane exposure on rainbow trout (Oncorhynchus mykiss) immunity. IV. Prevention of nonspecific and specific immunosuppression by dietary vitamin C (ascorbate-2-polyphosphate)

Ecotoxicology and Environmental Safety
M DunierV Verlhac

Abstract

The effect of the organochlorine insecticide lindane (gamma-hexachlorocyclohexane) administered intraperitoneally at 10 or 50 mg/kg body wt on some major immune functions of rainbow trout (Oncorhynchus mykiss) was examined. Fish were fed vitamin C as ascorbate-2-polyphosphate at a basal level (60 mg ascorbic acid-(AA)-equivalent/kg of feed) or a high level (2000 mg AA-equivalent/kg) 1 month before lindane exposure and during the whole experiment. The aim of the experiment was to determine whether dietary vitamin C is able to prevent immunosuppression due to lindane. The concentration of ascorbic acid in organs and the circulation was controlled, and the number of lindane residues in whole body was measured by gas chromatography. Nonspecific immune response was investigated through the determination of sera lysozyme and ceruloplasmin; both were significantly modified by lindane exposure while the immediate stimulating effects of vitamin C were observed. Cellular immunity was investigated by determining the number of B lymphocytes (analyzed by cytofluorometry) and their ability to proliferate with mitogens. One month after exposure to lindane (10 mg/kg) the proportion of Ig+ lymphocytes in head kidney was significantly decreased ...Continue Reading

Citations

Feb 24, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M BagniG Marino
Apr 1, 2014·Fish & Shellfish Immunology·Christopher A OttingerLuke R Iwanowicz
Aug 13, 2011·Ecotoxicology and Environmental Safety·Morgane DanionClaire Quentel
Apr 9, 2005·Ecotoxicology and Environmental Safety·Anna RymuszkaAdam Bownik
Apr 3, 1999·Toxicology and Industrial Health·I VocciaM Fournier
Nov 9, 2012·Journal of Aquatic Animal Health·Christopher A OttingerLuke R Iwanowicz
Mar 19, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Xianqing ZhouQingfen Li

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