PMID: 8615359May 1, 1996Paper

Effect of linoleic acid intake on growth of infants with cystic fibrosis

The American Journal of Clinical Nutrition
A W van EgmondP M Farrell

Abstract

Essential fatty acid deficiency as a result of inadequate linoleic acid impairs growth in healthy infants and is common in infants with malabsorption due to cystic fibrosis (CF). We investigated the effect of dietary linoleic acid intake on the growth of infants with CF. In this study, predigested formula preparations A and B, with linoleic acid contents of 12% and 7% of energy, respectively, were fed before and after 1989 to infants enrolled in the evaluation and treatment protocol of the Wisconsin CF Neonatal Screening Project. Outcome was assessed from height-for-age (HAZ) and weight-for-age (WAZ) Z scores on follow-up exams during the first year. Baseline characteristics did not differ significantly between groups A (n = 43) and B (n = 33). At diagnosis, 53% of the enrolled infants (n = 76) showed low plasma linoleic acid concentrations and 22% had a high ratio of triene to tetraene. After correcting for the effect of potentially confounding variables, we found that HAZ (by .27, P < 0.05) and WAZ (by 0.26, P = 0.081) were higher in group A than in group B. This occurred despite a significantly higher energy intake in group B. This difference was most pronounced between 6 and 9 mo of age. Our results suggest that a high lino...Continue Reading

Citations

Aug 19, 2007·The British Journal of Nutrition·Eva GronowitzBirgitta Strandvik
Sep 30, 2008·Clinical Reviews in Allergy & Immunology·Jack K Sharp, Michael J Rock
Oct 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Asim MaqboolVirginia A Stallings
Mar 8, 2018·Experimental Biology and Medicine·Birgitta StrandvikUlf Hammar
Feb 26, 1999·Pediatric Annals·S H Erdman
Jul 27, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Munir M ZamanSteven D Freedman
Nov 21, 2000·Pediatric Dermatology·G L DarmstadtV A Ziboh
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Kevin W SouthernA D Nagelkerke
Aug 17, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Neeraj Vij
May 8, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Stojka FustikSvetlana Koceva
Oct 7, 2016·Cellular and Molecular Life Sciences : CMLS·Carlo Castellani, Baroukh M Assael
Sep 13, 2014·International Journal of Molecular Sciences·Adam C Seegmiller
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·Jaroslaw WalkowiakMieczyslaw Walczak
Feb 18, 2016·Journal of Pediatric Gastroenterology and Nutrition·Vered DaitchLeonard Leibovici
Aug 5, 2003·Journal of the American College of Nutrition·Lisa G WoodManohar L Garg
Apr 7, 2020·Journal of the Academy of Nutrition and Dietetics·Miriam Isabel Souza Dos Santos SimonPaulo José Cauduro Marostica
Apr 4, 2021·International Journal of Molecular Sciences·Birgitta Strandvik
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M SinaasappelG Döring
Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lisa G WoodManohar L Garg
Mar 2, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jacqueline A JumpsenM T Clandinin
Feb 24, 2007·Clinical Biochemistry·Thierry Charles CosteTeresinha Leal
Apr 28, 2011·The Journal of Physical Chemistry. B·Fuwei PiYukihiro Ozaki
Feb 13, 2009·Colloids and Surfaces. B, Biointerfaces·Katarzyna Makyła, Maria Paluch
Feb 6, 2010·The Journal of Pediatrics·UNKNOWN Cystic Fibrosis FoundationFrank J Accurso

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