PMID: 9174229Apr 1, 1997Paper

Effect of lipid emulsion on IL-2 production by mononuclear cells of newborn infants and adults

Acta Paediatrica
L SirotaH Bessler

Abstract

The in vitro effect of a lipid emulsion (intralipid) on interleukin-2 (IL-2) production by cord blood mononuclear cells (CBMC) of preterm and term newborn infants was examined and compared to that of peripheral blood mononuclear cells (PBMC) of adults. Intralipid, added at concentrations accepted in clinical practice, caused a dose-dependent inhibition of IL-2 activity tested by bioassay. IL-2 levels, tested by radioimmunoassay (RIA), were found to be reduced only in supernatants derived from CBMC of term infants and not in those derived from MC of preterm infants or adults. The capacity of the IL-2 dependent cell line CTLL-2 to respond to IL-2 was abolished in the presence of intralipid, suggesting an interference with the binding of IL-2 to its receptor on these cells. It is conceivable that administration of intralipid to preterm infants may interfere with the binding of IL-2 to the specific receptors on their activated lymphocytes, with a possible subsequent suppression of their immune response.

References

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Citations

Apr 30, 2003·Journal of Pediatric Gastroenterology and Nutrition·Robert J Shulman, Sarah Phillips
Nov 23, 2011·European Journal of Pediatrics·Basma ShoumanMona F Salama
Dec 27, 2011·Journal of Reproductive Immunology·A S BansalM Y Thum
Feb 26, 2000·Clinics in Perinatology·G Putet

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