PMID: 8599607Feb 29, 1996Paper

Effect of lipid peroxidation on transferrin-free iron uptake by rabbit reticulocytes

Biochimica Et Biophysica Acta
Z M QianE H Morgan

Abstract

The relationship between lipid peroxidation and uptake of transferrin- free iron, Fe(II), by reticulocytes in an experimental system for studying membrane transport of Fe(II) was investigated by using free radical scavengers: BHA (butylated hydroxyanisole), BHT (butylated hydroxytoluene), superoxide dismutase, alpha-tocopherol, propyl gallate and DPPD (N,N-diphenyl-1,4-phenylenediamine), and producers: t-butyl hydroperoxide, cumene hydroperoxide, H2O2 and aluminium carbonate. Measurements were made of MDA (malondialdehyde) and the rate of Fe(II) uptake from a sucrose solution buffered at pH 6.5 by Pipes. Most scavengers and producers used could increase or decrease only slightly the rate of Fe(II) uptake and some of them had no effect on Fe(II) uptake and MDA could not be detected at iron concentration of lower than 10 microM and incubation time of 20 min. At iron concentration of higher than 100 microM and incubation time of 4 h, there was the production of MDA which increased with the increment of iron concentration of incubation medium and BHT could inhibit the production of MDA. In addition, no difference was found in the rates of Fe(II) uptake in three experimental groups whose incubation medium was buffered by Pipes, Mops...Continue Reading

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Citations

Jan 1, 1997·Progress in Biophysics and Molecular Biology·Z M QianQ Wang
Mar 1, 2002·Brain Research. Molecular Brain Research·Jun Xia XieZhong Ming Qian
Apr 1, 2014·Neurochemical Research·Yong LiuZhong-ming Qian
Dec 24, 2013·Translational Stroke Research·Xiao-Yi XiongQing-Wu Yang
Nov 20, 2015·Free Radical Biology & Medicine·Jing GongYa Ke
Sep 18, 2007·Progress in Neurobiology·Ya Ke, Zhong Ming Qian
Dec 27, 2011·Biochimica Et Biophysica Acta·Lei YangYa Ke
Jul 29, 2004·Journal of Cellular Physiology·Du Xiu-LianQian Zhong Ming
Jun 8, 2017·Frontiers in Physiology·Yu-Fu ZhouYa Ke
Sep 16, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Guang YangZhong-Ming Qian

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