Effect of lipid solubility on the development of chronic cross-tolerance between ethanol and different alcohols and barbiturates

Pharmacology, Biochemistry, and Behavior
J M KhannaG Shah

Abstract

Tolerance to ethanol and cross-tolerance to other alcohols (n-propanol, n-butanol, t-butanol, isobutanol, t-amyl alcohol, n-amyl alcohol, and benzyl alcohol) and barbiturates (pentobarbital, secobarbital, amobarbital, thiopental, barbital and phenobarbital) that differ in lipid:water partition coefficient was examined in rats after chronic pretreatment with ethanol. Tolerance and cross-tolerance were studied with three different measures (hypothermia, tilt-plane, and rotarod). Tolerance to ethanol resulted in significant cross-tolerance to alcohols with low lipid solubility (n-propanol and t-butanol), whereas no cross-tolerance was seen with alcohols of high lipid solubility (isobutanol, n-amyl alcohol, t-amyl alcohol and benzyl alcohol). Cross-tolerance to n-butanol (which has intermediate lipid solubility) appeared to be metabolic rather than functional. Tolerance to ethanol also resulted in significant cross-tolerance to barbital and phenobarbital, but not to pentobarbital, secobarbital, amobarbital or thiopental. These studies suggest that lipid solubility is an important factor in relation to specificity of cross-tolerance to alcohols and barbiturates.

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Citations

Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·R L BellW J McBride
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·J M KhannaG Shah
May 30, 2014·Pharmacology, Biochemistry, and Behavior·T J Etelälahti, C J P Eriksson
Jan 8, 2009·IEEE Transactions on Bio-medical Engineering·Martin H PlaweckiSean J O'Connor

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