PMID: 2493808Mar 14, 1989Paper

Effect of lipid transfer protein on plasma lipids, apolipoproteins and metabolism of high-density lipoprotein cholesteryl ester in the rat

Biochimica Et Biophysica Acta
J E GroenerA van Tol

Abstract

The role of human plasma lipid transfer protein (LTP) in lipoprotein metabolism was studied in the rat, a species without endogenous cholesteryl ester and triacylglycerol transfer activity. Partially purified human LTP was injected intravenously into rats. The plasma activity was between 1.5- and 4-fold that of human plasma during the experiments. 6 h after the injection of LTP, a significant increase in serum apoB, and no significant changes in serum total cholesterol, free cholesterol, triacylglycerols, apoA-I, apoE, or apoA-IV were noted. Cholesterol was increased in very-low density and low-density lipoproteins (VLDL and LDL) and decreased in large-sized apoE-rich HDL. ApoA-I-containing particles with a size smaller than in normal rats were present in serum of LTP-treated rats. The mean diameter of HDL particles decreased and apoE, normally present on large-sized HDL, was present on smaller sized particles. The metabolic fate of cholesteryl ester, originally associated with HDL, was studied by injection of [3H]cholesteryl linoleyl ether-labelled apoA-I-rich HDL in the absence and in the presence of LTP. The disappearance of [3H]cholesteryl linoleyl ether, injected as part of apoA-I-rich HDL, from serum was increased in the ...Continue Reading

References

Dec 1, 1975·The Journal of Clinical Investigation·O FaergemanR J Havel
Dec 17, 1975·Biochimica Et Biophysica Acta·D B ZilversmitJ Balmer
Jan 15, 1987·Biochemical and Biophysical Research Communications·R BarbarasG Ailhaud
Nov 14, 1986·Biochimica Et Biophysica Acta·D W Quig, D B Zilversmit
Dec 1, 1985·European Journal of Clinical Investigation·F M van't Hooft, A van Tol
Feb 8, 1985·Biochimica Et Biophysica Acta·Y C HaP J Barter
Oct 5, 1971·Biochimica Et Biophysica Acta·A Nilsson, D B Zilversmit
Mar 1, 1970·The Journal of Clinical Investigation·T G Redgrave
Dec 1, 1982·AJR. American Journal of Roentgenology·T HosokiS Mori
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P E Fielding, C J Fielding
Apr 1, 1980·Atherosclerosis·T KuusiE A Nikkilä
May 15, 1981·Biochemical and Biophysical Research Communications·A V NicholsP J Blanche
Jan 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·W O CASTERW D ARMSTRONG

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Citations

Sep 1, 1991·Diabetes/metabolism Reviews·T L Swenson
Dec 1, 1994·Lipids·C L BisgaierA White
Dec 16, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·V Guyard-DangremontC Lallemant
Aug 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G W MeijerA Van Tol
Sep 1, 1994·Clinical and Experimental Pharmacology & Physiology·P Barter, K A Rye
May 8, 2015·Journal of Lipids·Ravi Kant Upadhyay
Feb 8, 2011·Proteome Science·Shikha TanejaShahid Jameel
Jan 22, 2015·PloS One·Hussein N YassineRandall W Nelson
Jul 7, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Binita GoswamiSuresh Kumar
Jul 21, 2004·Trends in Cardiovascular Medicine·Uli C BroedlDaniel J Rader
Jun 28, 2005·International Journal of Cardiology·Tiziana SampietroAlberto Bionda
Oct 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R P DullaartA van Tol
Feb 1, 1991·Clinical Cardiology·J T Gwynne
Aug 4, 2019·Cancers·Konstantina GeorgilaElias Drakos
Apr 11, 2008·Clinical Science·Esther M M OoiGerald F Watts
Feb 19, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Ailhaud, P Guesnet
Apr 9, 2001·Infection and Immunity·J H LevelsS J van Deventer
Sep 26, 2014·Biological Chemistry·Nicole PrüferMarkus van der Giet
Nov 11, 2010·Journal of Clinical Periodontology·Özlem FentoğluF Yeşim Kırzıoğlu
Apr 2, 2013·Journal of Lipid Research·Anatol KontushM John Chapman
Dec 18, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Luciana Debortoli de CarvalhoEdel Figueiredo Barbosa-Stancioli
Aug 24, 1995·Biochimica Et Biophysica Acta·F TakahashiA Endo
May 23, 1998·Biochimica Et Biophysica Acta·K H ChoY B Park
Jan 11, 1994·Biochimica Et Biophysica Acta·M N PietersT J Van Berkel

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