Effect of lisinopril and atenolol on aortic stiffness in patients on hemodialysis

Clinical Journal of the American Society of Nephrology : CJASN
Panagiotis I Georgianos, R Agarwal

Abstract

Whether improvements in arterial compliance with BP lowering are because of BP reduction alone or if pleiotropic effects of antihypertensive agents contribute remains unclear. It was hypothesized that, among patients on hemodialysis, compared with a β-blocker (atenolol), a lisinopril-based therapy will better reduce arterial stiffness. Among 200 participants of the Hypertension in Hemodialysis Patients Treated with Atenolol or Lisinopril Trial, 179 patients with valid assessment of aortic pulse wave velocity at baseline (89 patients randomly assigned to open-label lisinopril and 90 patients randomly assigned to atenolol three times a week after dialysis) were included in the secondary analysis. Among them, 109 patients had a valid pulse wave velocity measurement at 6 months. Monthly measured home BP was targeted to <140/90 mmHg by addition of antihypertensive drugs and dry weight adjustment. The difference between drugs in percentage change of aortic pulse wave velocity from baseline to 6 months was analyzed. Contrary to the hypothesis, atenolol-based treatment induced greater reduction in aortic pulse wave velocity relative to lisinopril (between drug difference, 14.8%; 95% confidence interval, 1.5% to 28.5%; P=0.03). Reductio...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
May 11, 1999·Circulation·J BlacherG M London
Feb 5, 2002·American Journal of Hypertension·Ian B WilkinsonJohn R Cockcroft
Oct 9, 2002·Circulation·Martin HausbergKarl Heinz Rahn
Apr 1, 2004·The Korean Journal of Internal Medicine·Moo-Yong RheeYoung-Kwon Kim
Feb 2, 2006·American Journal of Hypertension·Zahid DhakamIan B Wilkinson
Oct 27, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Arjun D Sinha, Rajiv Agarwal
Apr 22, 2010·Journal of Hypertension·Ewa SwierblewskaKrzysztof Narkiewicz
Apr 29, 2010·Current Hypertension Reports·Michel E Safar
Apr 27, 2012·Kidney International·Marie BrietGérard M London
Sep 7, 2013·Current Vascular Pharmacology·Panagiotis I GeorgianosAnastasios N Lasaridis
Jan 7, 2014·Current Opinion in Nephrology and Hypertension·Maarten W Taal
Jan 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rajiv AgarwalGetachew G Tegegne
Apr 5, 2014·Journal of the American Society of Nephrology : JASN·Rajiv AgarwalMatthew R Weir
Jun 3, 2014·Journal of Hypertension·Gianfranco ParatiYuqing Zhang

❮ Previous
Next ❯

Citations

May 6, 2015·Nature Reviews. Nephrology·Cheuk-Chun Szeto, Philip Kam-Tao Li
Aug 31, 2016·Nature Reviews. Nephrology·Panagiotis I Georgianos, Rajiv Agarwal
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Panagiotis I Georgianos, Rajiv Agarwal
Oct 28, 2017·The Journal of Vascular Access·Damian G McGroganNicholas G Inston
Aug 8, 2018·Seminars in Dialysis·Panagiotis I Georgianos, Rajiv Agarwal
Mar 19, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Julio A Chirinos, Raymond R Townsend
Jul 25, 2018·Journal of Transcultural Nursing : Official Journal of the Transcultural Nursing Society·Zehra Gok MetinMustafa Cankurtaran
Aug 16, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·José M ValdivielsoAlberto Ortiz
Mar 14, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Panagiotis I GeorgianosPantelis E Zebekakis
Oct 26, 2018·Hypertension·Johannes B ScheppachMarkus P Schneider
Apr 14, 2020·Expert Opinion on Pharmacotherapy·Takashi MaruyamaMasanori Abe
Mar 5, 2020·Canadian Journal of Kidney Health and Disease·Rosendo A RodriguezKevin D Burns
Apr 4, 2020·Current Vascular Pharmacology·Panagiotis I GeorgianosVassilios Liakopoulos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.