Jan 1, 1977

Effect of lithium on the serotonin and kynurenine paths of tryptophan metabolism

Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova
I P KiselevaR A Khaunina

Abstract

Lithium carbonate in dosages from 50--100 mg/kg leads to an increase of tryptophanepyrrolase activity in the liver of rats from 50--80%, 5 hours following a single-time intraperitoneal administration and does not exert any influence after 1,3 and 20 hours. The same dosages (50 and 100 mg/kg) of lithium lead to an increase of II-hydroxycorticosteroids in in the blood plasma of rats to 2.5 times and could be prevented by a preliminary administration of dexametasone. A chronic administration of lithium (50 mg/kg) during 10 days did not exert any influence on the triptophanepyrrolase activity and the level of 11-hydroxycorticosteroids in the blood plasma of rats. These data permit of assume that an increase of tryptophanepyrrolase activity by lithium is moderated by an increase of II-hydroxycorticosteroids in the blood.

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Mentioned in this Paper

Exertion
11-Hydroxycorticosteroids
Kynurenine
Serotonin Measurement
Serotonin
Lithium Measurement
Tryptophan Metabolism Pathway
Adrenalectomy
Plasma
Lithium Carbonate

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