Effect of lithospermi radix on contact dermatitis induced by dinitrofluorobenzene in mice

Journal of Pharmacopuncture
Hanna KimHyungwoo Kim

Abstract

The root of Lithospermum erythrorhizon Sieb. et Zucc. (Lithospermi Radix, LR) is a kind of heat clearing and blood cooling medicinal herbs. It can clear away heat and cool the blood, reduce toxins and disperse maculae. LR has long been used as efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4- dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model. Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB. Topical application of LR also inhibited hyperplasia, edema, spongiosis and infiltrations of mononuclear cells. In addition, production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo. These data suggest that LR acts as an antiinflammatory agent, improving skin lesions in CD mice.

References

Jan 1, 1988·International Archives of Allergy and Applied Immunology·G H BoerrigterR J Scheper
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·J Machado-PintoL E Golitz
Aug 11, 2001·The Journal of Allergy and Clinical Immunology·D H Broide
Aug 26, 2004·Dermatologic Therapy·David E Cohen, Noushin Heidary
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Ming-Chun WenXiu-Min Li
Nov 17, 2006·The Journal of Investigative Dermatology·David R Bickers, Mohammad Athar

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Skin NBT
SigmaPlot

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