Effect of liver transplantation on the hypothalamic-pituitary-gonadal axis of chronic alcoholic men with advanced liver disease

Alcoholism, Clinical and Experimental Research
D H van ThielR E Tarter

Abstract

The hormones testosterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) were assayed in blood obtained from men with alcoholic liver disease before and after successful liver transplantation. The frequency and severity of self reported impotence, intercourse, and paternity were assessed before and 18 +/- 3 months post-transplantation. The results obtained were compared with those of age-matched males transplanted within the same month by the same surgical teams for advanced hepatocellular disease other than alcoholism. Little change for any parameter assessed pre- and post-transplantation was noted for the nonalcoholics. In contrast, the FSH, LH, and testosterone levels of the alcoholic men all increased significantly following successful transplantation. These data suggest that the liver disease associated with alcoholism contributes to some of the endocrine effects of alcohol-associated cirrhosis but not all. Because the transplanted alcoholics remain less adequate than controls, it is further suggested that some residual alcohol-induced injury to the hypothalamic-pituitary-gonadal axis persists despite successful liver transplantation.

References

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Citations

Jul 1, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·D M BravataD K Owens
Mar 12, 2002·Journal of Endocrinological Investigation·R AllerD A de Luis
Nov 1, 1993·Disease-a-month : DM·W D Odell, H Heath
Feb 19, 2008·Journal of Hepatology·Santiago TomeMichael R Lucey
Aug 22, 2008·Journal of Hepatology·Michael A HeneghanBeat Mullhaupt
May 11, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Karim GarianiLorenzo A Orci
Jun 3, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James H Sorrell, Jill R Brown
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K A Brown, M R Lucey
Apr 2, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Elisa VaianiAlicia Belgorosky
Dec 15, 2020·World Journal of Transplantation·Ioannis A ZiogasGeorgios Tsoulfas
Nov 26, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sophie L AllenLeigh Breen

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