Effect of liver transplantation on transthyretin Tyr114Cys-related cerebral amyloid angiopathy

Neurology
T YamashitaM Uchino

Abstract

Patients with amyloidogenic transthyretin (ATTR) Tyr114Cys develop amyloid deposits in cerebral blood vessels, cerebral hemorrhage, and rapidly progressive dementia that presents with hereditary cerebral amyloid angiopathy (CAA). However, no treatment has been identified for CAA. Although liver transplantation has become an acceptable treatment of TTR-related amyloidosis, liver transplantation may not successfully treat CNS manifestations of the disorder. In this study, we examined the effect of liver transplantation on these manifestations of TTR-related CAA. We compared clinical courses of three patients with CAA associated with ATTR Tyr114Cys who underwent liver transplantation with those of five patients with the disorder who did not undergo liver transplantation. The mortality and occurrence of cerebral hemorrhage and dementia in patients having transplantations were reduced compared with those in patients not having transplantations. The two groups did not differ with regard to the frequency of episodes of fluctuating consciousness and TIAs. The group undergoing transplantations had significantly smaller volumes of intracranial hemorrhage than did the no-transplantation group. Liver transplantation was effective for CNS m...Continue Reading

Citations

Aug 16, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·T YamashitaM Uchino
Aug 16, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·L LobatoR Almeida
Jan 15, 2016·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Kosuke OkumuraYukio Ando
May 14, 2010·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Merrill D BensonBrett P Monia
Nov 20, 2009·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Ole B SuhrPer Westermark
May 12, 2016·Journal of Internal Medicine·M AnkarcronaJ W Kelly
Dec 8, 2010·Neuro-degenerative Diseases·Yu ZhangSheng-Di Chen
Nov 26, 2016·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Paula GonçalvesMaria Joao Saraiva
Jun 2, 2018·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Haruki KoikeMasahisa Katsuno
Oct 9, 2018·Acta Neurologica Scandinavica·Josef FinstererWolfgang Grisold
Jul 26, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Aito IsoguchiYukio Ando
Jul 26, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Taro YamashitaYukio Ando
Dec 7, 2018·Biological & Pharmaceutical Bulletin·Yuya Hayashi, Hirofumi Jono

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