Effect of local anaesthetic wound infiltration on acute pain and bleeding after primary total hip arthroplasty: the EDIPO randomised controlled study

International Orthopaedics
Guillaume VillatteStéphane Descamps

Abstract

Total hip arthroplasty (THA) is considered a painful procedure with significant blood loss. The aim of the this study was to determine whether local infiltration analgaesia (LIA) (with long-acting local anaesthetics and epinephrine) during THA could reduce acute postoperative pain, improve early recovery and reduce per- and postoperative bleeding. One hundred and fifty patients scheduled for primary THA were randomised into two groups. The treatment group received LIA (ropivacaine with epinephrine), whereas the control group had no infiltration. Pain intensity was measured with a visual analogue scale (VAS) for the duration of hospital stay and analgaesic consumption. Length of hospital stay, time to get out of bed alone and the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index at 3, 6 and 12 months were recorded to evaluate recovery. Per- and postoperative bleeding were evaluated using direct and indirect criteria (operative blood loss, haemoglobin, estimation of uncompensated blood loss and red blood cell transfusion). Patients with LIA had significantly less pain during the first 24 h (p = 0.04). No significant differences were found in terms of analgaesic consumption (p = 0.57), early and delayed recove...Continue Reading

References

Jan 1, 1996·Current Medical Research and Opinion·F Mercuriali, G Inghilleri
Apr 25, 2008·British Journal of Anaesthesia·W A Macrae
Feb 18, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·UNKNOWN Société française d'anesthésie et de réanimation
Mar 11, 2011·Orthopaedics & Traumatology, Surgery & Research : OTSR·V WyldeA Blom
Apr 6, 2011·Acta Anaesthesiologica Scandinavica·Henrik Kehlet, L Ø Andersen
May 18, 2011·The Open Orthopaedics Journal·Jasvinder A Singh
Jul 26, 2012·Anesthesiology Research and Practice·Denise McCarthy, Gabriella Iohom
Jul 31, 2012·International Orthopaedics·Spencer S LiuThomas P Sculco
Jan 22, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·E IrissonL Bellamy
Feb 7, 2013·International Orthopaedics·Emmanuel GibonMoussa Hamadouche
Mar 22, 2013·British Journal of Anaesthesia·K V AndersenK Søballe
Dec 3, 2013·The Bone & Joint Journal·M S IbrahimF S Haddad
Apr 9, 2014·The Journal of Pain : Official Journal of the American Pain Society·Jun-Bin YinWen Wang
Jun 19, 2014·British Journal of Anaesthesia·L Ø Andersen, H Kehlet

❮ Previous
Next ❯

Citations

Mar 1, 2020·Der Orthopäde·Dr M KriegerT Hartmann
May 28, 2019·Deutsches Ärzteblatt International·Dominik GeilWinfried Meissner
Oct 29, 2020·Orthopaedics & Traumatology, Surgery & Research : OTSR·Aymard De LadoucetteUNKNOWN French Society of Orthopaedic Surgery and Traumatology (SoFCOT)
May 21, 2021·Anaesthesia·M AngerUNKNOWN PROSPECT Working Group* and the European Society of Regional Anaesthesia and Pain Therapy
Oct 2, 2021·Journal of Wound Care·Mehmet TapanMustafa Agah Tekindal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.