Effect of local application of transcutaneous carbon dioxide on survival of random-pattern skin flaps

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
Izumi SaitoTakahide Komori

Abstract

Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis. We investigated whether transcutaneous CO2 application can increase the survival of random-pattern skin flaps. Six-week-old male Sprague-Dawley rats were divided into two equal groups: the control group (n = 6) and CO2 group (n = 6). A random-pattern skin flap was constructed in these rats. Topical CO2 was applied using a hydrogel every day for 5 days in the CO2 group. The flap survival area was measured on postoperative days 1, 3, and 5. The vessel density and expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor-1α (HIF-1α) were evaluated on postoperative day 5. A statistically significant difference was f...Continue Reading

Citations

Jun 17, 2020·International Journal of Cosmetic Science·Satoko FukagawaTakatoshi Murase
Jan 29, 2021·Oxidative Medicine and Cellular Longevity·Hongyu ChenBin Zhao
Feb 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mingchen XiongYiping Wu
May 3, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Tianli HuangBin Zhao

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