Effect of local chain dynamics on a bioinert interface

Langmuir : the ACS Journal of Surfaces and Colloids
Toyoaki HirataKeiji Tanaka

Abstract

Although many kinds of synthetic polymers have been investigated to construct blood-compatible materials, only a few have achieved success. To establish molecular designs for blood-compatible polymers, the chain structure and dynamics at the water interface must be understood using solid evidence as the first bench mark. Here we show that polymer dynamics at the water interface impacts on structure of the interfacial water, resulting in a change in protein adsorption and of platelet adhesion. As a particular material, a blend composed of poly(2-methoxyethyl acrylate) (PMEA) and poly(methyl methacrylate) was used. PMEA was segregated to the water interface. While the local conformation of PMEA at the water interface was insensitive to its molecular weight, the local dynamics became faster with decreasing molecular weight, resulting in a disturbance of the network structure of waters at the interface. This leads to the extreme suppression of protein adsorption and platelet adhesion.

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May 16, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Ayanobu HorinouchiKeiji Tanaka

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Citations

Sep 16, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Settimio PacelliArghya Paul
Dec 16, 2016·Physical Chemistry Chemical Physics : PCCP·Toyoaki HirataKeiji Tanaka
Jun 16, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Takuma Kureha, Daisuke Suzuki
Aug 8, 2017·Physical Chemistry Chemical Physics : PCCP·Narendra M AdhikariKatherine L A Cimatu
Mar 7, 2020·Journal of Biomaterials Science. Polymer Edition·Akira MochizukiTsubasa Kawaguchi
Dec 15, 2020·Colloids and Surfaces. B, Biointerfaces·Masaru TanakaTomohiro Hayashi
Nov 5, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Haiye WangChunju He
Dec 7, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Nozomi ItagakiKeiji Tanaka
Apr 14, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Kanta YanagiHideaki Yokoyama
Sep 26, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Hidenobu TanedaKeiji Tanaka

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