Effect of local heating on restenosis and in-stent neointimal hyperplasia in the atherosclerotic rabbit model: a dose-ranging study

European Heart Journal
Camille BrasseletAntoine Lafont

Abstract

In-stent restenosis is related to neointimal hyperplasia. Heating reduces neointimal hyperplasia but promotes constrictive remodeling after balloon angioplasty. We aimed to assess the ability of local heating in inhibiting restenosis and in-stent neointimal hyperplasia and its potential side effects on arterial thrombosis. Atherosclerotic-like lesions were induced in iliac rabbit arteries. One month later, both iliac rabbit arteries were stented. In each animal, one artery was randomized to local heating at four temperatures (50, 60, 80, and 100 degrees C). The contra lateral artery was used as control. Angiographic and histomorphometric analysis were performed 42 days after angioplasty. Immunohistochemistry was performed 3, 15, and 42 days after angioplasty. Angiographic significant reduction of in-stent restenosis after moderate heating (50 degrees C) was related to in-stent neointimal hyperplasia trend to be lower after moderate local heating when compared with controls. In contrast, in-stent thrombosis was similar to controls. Higher temperatures (i.e. 80 and 100 degrees C) also reduced in-stent neointimal hyperplasia but were most frequently associated with severe in-stent thrombosis. Local heating was associated with decr...Continue Reading

Citations

Jun 22, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Eric DurandAntoine Lafont
Jul 1, 2015·International Journal of Clinical Oncology·Saranatra WaikakulRapin Phimolsarnti
Apr 21, 2016·Revista do Colégio Brasileiro de Cirurgiões·Jânio Cipriano RolimAdamastor Humberto Pereira
Oct 19, 2019·Advanced Healthcare Materials·Ying YiKenichi Takahata
Jan 24, 2019·BioMed Research International·Qiang ChenGuangping Li
Jun 12, 2020·Biomedical Engineering Online·Shiqing ZhaoLisa X Xu
Aug 8, 2018·ACS Applied Materials & Interfaces·Jung-Hoon ParkHo-Young Song

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