Effect of locally administered novel biodegradable chitosan based risedronate/zinc-hydroxyapatite intra-pocket dental film on alveolar bone density in rat model of periodontitis

Journal of Biomaterials Science. Polymer Edition
Deepak Kumar KhajuriaRema Razdan

Abstract

The aim of this study was to develop a chitosan-based risedronate/zinc-hydroxyapatite intrapocket dental film (CRZHDF) for applications in the treatment of alveolar bone loss in an animal model of periodontitis. The physical characteristics (folding endurance, pH, mucoadhesive strength, risedronate content and release) of CRZHDF, exhibited results within the limit. X-ray diffraction analysis indicates reduced or disappeared crystallinity of risedronate and zinc-hydroxyapatite in presence of chitosan. Further, FTIR studies revealed stability of CRZHDF and compatibility between risedronate, zinc-hydroxyapatite and chitosan. Periodontitis was induced by Porphyromonas gingivalis-lipopolysaccharide injections around the mandibular first molar. We divided rats into 5 groups (12 rats/group): healthy, untreated periodontitis; periodontitis plus CRZHDF-A, periodontitis plus CRZHDF-B, and periodontitis plus chitosan film. After four weeks, blood samples and mandibles were obtained for biochemical, radiographic and histological analysis. Bone specific alkaline phosphatise activity and tartrate resistant acid phosphatase 5b was statistically lower in CRZHDF-A and CRZHDF-B groups as compared to the untreated periodontitis group (p < 0.0001)...Continue Reading

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Citations

Mar 16, 2018·The Open Dentistry Journal·Maha Ahmad
Oct 28, 2019·Oral Diseases·Adrian BrunElisabeth Dursun
Apr 3, 2020·Nutrients·Anne Marie UwitonzeMohammed S Razzaque
Oct 19, 2019·IET Nanobiotechnology·Debalina BhattacharyaMainak Mukhopadhyay
Apr 21, 2020·Current Medicinal Chemistry·Jiliang MaRuncang Sun
Jul 1, 2020·International Journal of Biological Macromolecules·Elaheh FakhriHossein Samadi Kafil

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Methods Mentioned

BETA
X-Ray
scanning
enzyme-linked immunosorbent assay

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