PMID: 9546276Apr 18, 1998Paper

Effect of locally applied drugs on the endolymphatic sac potential

The Laryngoscope
V CouloignerE Ferrary

Abstract

In Ménière's disease, an inner ear disorder related to an endolymphatic hydrops, an alteration of the functioning of the endolymphatic sac has been proposed. The endolymphatic sac is assumed to be involved in the secretion/resorption of endolymph. The epithelial transport systems have been indirectly studied by the recording of the endolymphatic sac transepithelial potential (ESP) in control conditions and after the local injection of drugs such as diuretics that have been proposed in the treatment of Ménière's disease. The ESP was recorded, in vivo, in guinea pigs up to 150 minutes after the perisaccular injection of 5 microL of a 150 mmol/L (mM) NaCl solution containing various drugs known to inhibit ionic transport systems. The initial ESP was +8.4+/-0.3 mV (mean +/- SEM, n = 78). The basolateral injection of 5 microL of 150 mM NaCl induced an ESP decrease of 64%+/-6.0% (n = 12), 5 minutes after the end of the injection. Then ESP increased, returning to its initial value at 60 minutes and surpassing it at 120 minutes. Diuretics such as acetazolamide (10[-3] mol/L [M]), an inhibitor of carbonic anhydrase, and amiloride (10[-4] M), an inhibitor of Na channel or Na/H exchanger, decreased the ESP recovery. At variance, bumetanid...Continue Reading

References

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Citations

Oct 22, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hyeyoung Kim
Nov 16, 2002·Hearing Research·Kelli PettitAlec N Salt
Sep 13, 2000·The Laryngoscope·S D RauchK J Bloch
Jul 20, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Maroun T Semaan, Cliff A Megerian
Mar 21, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sung Huhn KimJae Young Choi
Apr 7, 2004·Médecine sciences : M/S·Vincent CouloignerEvelyne Ferrary
Jun 29, 2004·Hearing Research·Hidetaka KumagamiHaruo Takahashi
Oct 22, 2016·Acta Oto-laryngologica·Masaya TakumidaMatti Anniko
Nov 3, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Nozomu MoriHiroshi Hoshikawa
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V CouloignerE Ferrary

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