PMID: 11320899Apr 26, 2001Paper

Effect of locally applied GM-CSF on oral mucositis after stem cell transplantation: a prospective placebo-controlled double-blind study

Annals of Hematology
H van der LelieA E von dem Borne

Abstract

Oral mucositis is a frequent side effect of myeloablative chemo- and radiotherapy preceding stem cell transplantation. It causes pain, poor food intake, and is a port of entry for infection. We studied whether GM-CSF applied topically in the oral cavity can prevent or ameliorate this mucositis. In 36 consecutive patients undergoing a stem cell transplantation, we performed a double-blind placebo-controlled study of 300 micrograms GM-CSF in a 2% methylcellulose gel daily versus a 2% methylcellulose gel alone. Both were locally applied in the oral cavity. The primary end-point was mucositis as measured by the WHO toxicity scale for mucositis, oral assessment scale, and a subjective pain scale, all scored daily. The secondary end-points were need to give parenteral nutrition and morphine, incidence of fever and infections, and duration of neutropenia and hospitalization. No differences were found in the median subjective pain scores, WHO scores, and oral assessment scores between the placebo and the GM-CSF groups. In both groups, nine patients required morphine for pain control. Ten patients in the placebo group and 11 in the GM-CSF group received parenteral nutrition. Documented infections, use of broad-spectrum antibiotics, and ...Continue Reading

Citations

Jun 16, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Inger von BültzingslöwenDorothy Keefe
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C C van der Rijt, L van Zuijlen
Sep 19, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Judith E Raber-DurlacherUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Nov 12, 2013·Journal of Pain and Symptom Management·Kunal C KadakiaCharles L Loprinzi
Nov 9, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Barry QuinnLena Sharp
May 17, 2006·Oral Diseases·C ScullyP D Diz
Apr 27, 2004·Cancer·Edward B RubensteinUNKNOWN International Society for Oral Oncology
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Helen V WorthingtonTasneem Khalid
Feb 23, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Richard M LoganUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Nov 29, 2017·The Cochrane Database of Systematic Reviews·Philip RileyMartin G McCabe

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