PMID: 1209162Dec 1, 1975Paper

Effect of long-term administration of ethanol to the rat: lipids, collagen and other proteins, and Mallory bodies in the liver

Scandinavian Journal of Clinical and Laboratory Investigation
H M HäkkinenE Kulonen

Abstract

Rats drank ethanol, on the average 1.20 g/100 g body weight, for various periods up to nearly 300 days. Experimental variables included a high-fat, low-protein diet, administration of additional ethanol by stomach tube, and CCl4 injections instead of ethanol. Growth was retarded by all the variables, especially by the high-fat, low-protein diet. The specific histological finding in the ethanol groups was the presence of Mallory bodies. Significant increase in total liver lipids was caused by ethanol, and rapid fat accumulation, inflammatory changes, and even fibrosis and cirrhosis by the high-fat, low-protein diet and the CCl4 injections. Ethanol raised the concentrations of collagen and soluble protein in the liver; the collagen content was increased also by the high-fat, low-protein diet and the CCl4 injections. The incorporation of proline to collagen was stimulated in incubated liver slices from both ethanol-treated and high-fat, low-protein-fed rats. These treatments also increased the concentration of free proline in the liver, thus augmenting the protein synthesis in fibroblasts.

References

Jan 15, 1975·Biochemical Pharmacology·H M Hkkinen, E Kulonen
Jun 1, 1971·The American Journal of Clinical Nutrition·J TakeuchiY Matsuda
Jan 17, 1974·The New England Journal of Medicine·E Rubin, C S Lieber
Apr 1, 1974·The Biochemical Journal·R A HawkinsR L Veech
Apr 1, 1973·The Biochemical Journal·M AaltoE Kulonen
Nov 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Stegemann, K Stalder
Mar 1, 1972·The Biochemical Journal·K N JeejeebhoyU Sodtke
Jun 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J P Comstock, S Udenfriend
Mar 1, 1967·Medicine·U HarinasutaH J Zimmerman
Apr 1, 1970·The Journal of Clinical Investigation·E Baraona, C S Lieber
Dec 1, 1970·The Journal of Clinical Investigation·D KershenobichM Rojkind
Jul 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Huberman, G Soberon
Sep 1, 1971·The Journal of Clinical Investigation·M A RothschildS S Schreiber
Feb 22, 1971·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·K KuriyamaG E Rauscher
Apr 1, 1966·Analytical Biochemistry·K Juva, D J Prockop
Oct 1, 1967·The Biochemical Journal·K Lampiaho, E Kulonen
Jan 1, 1967·Biochimica Et Biophysica Acta·G A FinermanL E Rosenberg
Feb 13, 1964·The New England Journal of Medicine·K J ISSELBACHER, N J GREENBERGER

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Citations

Jan 1, 1979·Biochemical Pharmacology·J MørlandL Svendsen
Aug 1, 1987·Journal of Hepatology·C BodeJ C Bode
Mar 6, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Yaping LiShuangsuo Dang
Oct 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Jensen, C Gluud
Jan 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E MezeyC H Halsted
Dec 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·I LautenschlagerE Kulonen
Jan 1, 1980·Scandinavian Journal of Gastroenterology·J TyöppönenE Kulonen
May 15, 1980·Biochemical Pharmacology·H M Häkkinen, E Kulonen
Jan 20, 1977·Biochimica Et Biophysica Acta·J Mørland, A Bessesen

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