Effect of long-term antibiotic use on weight in adolescents with acne

The Journal of Antimicrobial Chemotherapy
Despina G Contopoulos-IoannidisJulie Parsonnet

Abstract

Antibiotics increase weight in farm animals and may cause weight gain in humans. We used electronic health records from a large primary care organization to determine the effect of antibiotics on weight and BMI in healthy adolescents with acne. We performed a retrospective cohort study of adolescents with acne prescribed ≥4 weeks of oral antibiotics with weight measurements within 18 months pre-antibiotics and 12 months post-antibiotics. We compared within-individual changes in weight-for-age Z-scores (WAZs) and BMI-for-age Z-scores (BMIZs). We used: (i) paired t-tests to analyse changes between the last pre-antibiotics versus the first post-antibiotic measurements; (ii) piecewise-constant-mixed models to capture changes between mean measurements pre- versus post-antibiotics; (iii) piecewise-linear-mixed models to capture changes in trajectory slopes pre- versus post-antibiotics; and (iv) χ(2) tests to compare proportions of adolescents with ≥0.2 Z-scores WAZ or BMIZ increase or decrease. Our cohort included 1012 adolescents with WAZs; 542 also had BMIZs. WAZs decreased post-antibiotics in all analyses [change between last WAZ pre-antibiotics versus first WAZ post-antibiotics = -0.041 Z-scores (P < 0.001); change between mean W...Continue Reading

References

Nov 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·C D LeesE Steiger
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J AcarH Goossens
Oct 20, 2001·The New England Journal of Medicine·S L Gorbach
Apr 25, 2003·Poultry Science·J A Patterson, K M Burkholder
May 10, 1955·The Journal of Nutrition·T H HAIGHT, W E PIERCE
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Nov 18, 2004·Journal of Pediatric Surgery·Yutaka KanamoriRyuichiro Tanaka
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Sep 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter CollignonColin D Butler
Feb 2, 2006·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·N VendtR Korpela
Jun 3, 2006·Science·Steven R GillKaren E Nelson
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc-Emmanuel DumasJeremy K Nicholson
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jan 6, 2007·Pediatric Surgery International·Keiichi UchidaMasato Kusunoki
Jan 24, 2007·Public Health Reports·Jay P GrahamEllen Silbergeld
Mar 7, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D Raoult
Apr 3, 2008·Mayo Clinic Proceedings·John K DiBaiseBruce E Rittmann
Sep 10, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S H DuncanH J Flint
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 4, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·I NadalY Sanz
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Husen ZhangRosa Krajmalnik-Brown
Apr 25, 2009·Obesity·Arlette SantacruzUNKNOWN EVASYON Study Group
Mar 6, 2010·Science·Matam Vijay-KumarAndrew T Gewirtz
Apr 7, 2010·Science Translational Medicine·Peter J TurnbaughJeffrey I Gordon
Apr 28, 2010·Medical Care·Eric C WongDiane S Lauderdale
Jun 15, 2010·The Proceedings of the Nutrition Society·Yolanda SanzPaola Gauffin
Mar 10, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T A AjslevT Jess
May 7, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·M Al-HosniR Soll
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Aug 22, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L TrasandeM J Blaser
Feb 1, 2013·The New England Journal of Medicine·Indi TrehanMark J Manary
Feb 1, 2013·Science·Michelle I SmithJeffrey I Gordon
Sep 28, 2013·The Lancet Infectious Diseases·Emmanouil AngelakisDidier Raoult
Nov 22, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R MurphyUNKNOWN ISAAC Phase Three Study Group
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Jul 6, 2014·Frontiers in Microbiology·Moussa S Diarra, François Malouin
Jul 12, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M B AzadA L Kozyrskyj

❮ Previous
Next ❯

Citations

Aug 18, 2016·Gut·Gianluca IaniroAntonio Gasbarrini
Oct 6, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Mark LownPaul Little

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.