PMID: 7030749Jan 1, 1981Paper

Effect of long-term beta-blockade with alprenolol on platelet function and fibrinolytic activity in patients with coronary heart disease

European Journal of Clinical Pharmacology
H J JürgensenJ Gormsen

Abstract

In 14 patients with coronary heart disease the effect of long-term treatment (mean 16 months, range 12-33) with alprenolol on platelet function and fibrinolytic activity was studied. While on the beta-blocker and two weeks after gradual withdrawal of it, the patients performed a bicycle-ergometer test and blood samples were obtained before and following exercise. Pre-exercise fibrinolytic activity, assessed by the euglobulin clot lysis time, was 183 +/- 27 min (mean +/- SEM) while on alprenolol as compared to 111 +/- 18 min (p less than 0.01) after its withdrawal. Activation of fibrinolysis following exercise was not significantly influenced by alprenolol. In patients treated with alprenolol, the pre-exercise threshold level of ADP, producing platelet aggregation was 3.3 muM (geometric mean) and 5.1 muM after stopping treatment (p less than or equal to 0.05). In patients receiving the beta-blocker, the ADP- threshold value dropped from 3.3 muM before exercise to 2.3 muM immediately after exercise (not significant). The corresponding values after withdrawal of alprenolol were 5.1 muM and 2.7 muM (p less than or equal to 0.02). Adrenaline - stimulated aggregation was not significantly influenced by alprenolol. Serotonin release f...Continue Reading

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Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·K WintherE Eldrup
Jan 1, 1986·European Journal of Clinical Pharmacology·K WintherJ Jensen
May 10, 2012·Headache·Piet Borgdorff, Geert Jan Tangelder
Apr 16, 2014·British Journal of Clinical Pharmacology·Tobias N BontenJohanna G van der Bom
Apr 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G AnfossiG Emanuelli
Nov 23, 2013·Revista brasileira de anestesiologia·Emine Arzu KoseVedat Yildirim
Dec 15, 1985·Thrombosis Research·K WintherP H Andersen
Jun 20, 2018·CPT: Pharmacometrics & Systems Pharmacology·Yun HaoNicholas P Tatonetti
Aug 1, 1982·Acta Neurologica Scandinavica·J Dalsgaard-NielsenI Zeeberg
Dec 1, 1983·British Journal of Clinical Pharmacology·A MarkelM B Youdim
Jan 1, 1984·Acta Medica Scandinavica. Supplementum·H J Jürgensen

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