Effect of long-term feeding of the Obudu natural honey and table sugar-sweetened diets on obesity and pro-inflammatory biomarkers in rats

BMC Nutrition
Item Justin AtangwhoPromise Nwankpa

Abstract

This study investigated long-term effect of the Obudu honey on selected biomarkers of energy storage regulation, compared to table sugar. Fifty Wistar rats assigned to 5 groups of 10 rats each, were fed rat chow only (NC), 8% table sugar (S8%), 16% table sugar (S16%), 10% honey (H10%) and 20% honey (H20%) diets respectively, for 29 weeks. On dry weight basis, the percentages of table sugar and honey for each level of incorporation were equivalent. Diet intake, body weights and fasting blood glucose (FBG) were measured fortnightly. At the end of the study, serum glucose, insulin, leptin and tissue necrosis factor - α (TNF-α), wet weight of white adipose tissues (WAT) were measured. After an initial adjustment to the diets, there was no significant difference in diet consumed by female and male subgroups, except the female group fed H20% which was consistently lower than the NC and the corresponding S16% fed group (P < 0.05). Both honey and sugar incorporated diets caused significant body weight gain in the female animals compared to NC; an effect which was higher with the honey than sugar, and depended on the level of each sweetener used as well as feeding duration (P < 0.05). Furthermore, S8% and S16% diets increased leptin con...Continue Reading

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Citations

Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siti Sarah Mohamad ZaidMohd Helmy Mokhtar

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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