Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Sulochana DeviJacob Joseph

Abstract

Postulated mechanisms of hyperhomocysteinemia (Hhe) overlap with proposed mechanisms of adverse cardiac remodeling such as altered collagen metabolism and oxidant stress. Hence we examined the hypothesis that Hhe would promote myocardial fibrosis and systolic dysfunction. Three-month-old spontaneously hypertensive rats (SHRs) were divided into three groups: (1) control, given amino-acid defined diet for 20 weeks; (2) Hhe group, given Hhe-inducing diet for 20 weeks; and (3) combined diet group, which were given Hhe-inducing diet for 10 weeks (which leads to myocardial fibrosis and diastolic dysfunction as shown in our prior studies) and subsequently returned to amino acid-defined diet for 10 more weeks. At the end of the treatment period, plasma homocysteine (Hcy) levels and blood pressure were measured, and hearts were isolated for histomorphometric and biochemical assessment of cardiac remodeling and myocardial oxidative stress, and for in vitro cardiac function studies. The Hhe animals demonstrated a significant increase in the ratio of collagenous to noncollagenous protein due to reactive interstitial fibrosis, and increased myocardial oxidant stress, compared to the control group. Systolic function was significantly depress...Continue Reading

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Citations

Apr 29, 2009·Cardiovascular Toxicology·Omid Taban-ShomalMarkus Herrmann
Jun 2, 2009·Cardiovascular Toxicology·Jacob JosephJoseph Loscalzo
Apr 9, 2013·European Journal of Pharmacology·Athina A StrilakouCharis A Liapi
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Nov 17, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ankur Rohilla, Pitchai Balakumar
Jan 16, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Christian MühlfeldTerry M Mayhew
Dec 11, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Wolfgang HerrmannSuresh C Tyagi
Oct 31, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jacob JosephRichard H Kennedy
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Jul 8, 2011·The Journal of Pathology·Jacob Joseph
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Jun 28, 2019·Cardiovascular Research·Christian Riehle, Johann Bauersachs
Feb 17, 2007·Clinical Chemistry·Markus HerrmannWolfgang Herrmann
Feb 19, 2020·Der Nervenarzt·Michael MartinAxel Karenberg
Jun 4, 2008·Journal of Cardiovascular Pharmacology·Amrit Pal SinghPitchai Balakumar
Oct 13, 2010·Molecular and Cellular Biochemistry·Lamia RaafNathalie Janel
Aug 5, 2019·Acta histochemica·Billel ChaouadYasmina Benazzoug
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Feb 21, 2021·Biochemical and Biophysical Research Communications·Ping CaoRui Xu
Jan 23, 2019·The American Journal of the Medical Sciences·LiangLiang ZhangJacob Joseph

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