Effect of long-term in vitro testing on the properties of bioactive glass-polysulfone composites

Biomacromolecules
Rodrigo OréficeAnthony Brennan

Abstract

The combination of bioactive ceramics and polymers can allow the preparation of composites with tailorable mechanical properties and bioactive behavior. In these composites, bioactive ceramics can act as a source of both reinforcement and bioactivity, while the polymer matrix can add toughness and processability to the material. On the other hand, the effect of using a highly dimensional unstable phase as a reinforcing agent on the long-term properties of the composite is a major concern regarding the lifetime of possible applications. In this work, a bioactive glass-polysulfone particulate composite was prepared by hot-pressing at 215 degrees C a mixture of polysulfone and different concentrations of bioactive glass particles (Bioglass 45S5, particle size range: 125-106 microm) to yield composites having 20 and 40 vol % of bioactive glass particles. The obtained composites were exposed to a simulated body fluid at 37 degrees C for different periods of time ranging from 1 h to 60 days. After the test, the mechanical properties of the composites were investigated by a four-point bending test, while DMS (dynamic mechanical spectroscopy) was used to identify the effect of water on the structure and behavior of the composite. The i...Continue Reading

References

Nov 22, 1997·Journal of Biomedical Materials Research·M MarcolongoW C LaCourse
Jan 16, 1998·Journal of Biomedical Materials Research·M MarcolongoE Schepers
Apr 5, 2001·Journal of Biomedical Materials Research·R L OréficeA B Brennan
Oct 13, 2006·Journal of Biomedical Materials Research. Part a·Rodrigo OréficeLarry Hench
Mar 30, 2007·Acta Biomaterialia·Georgia Chouzouri, Marino Xanthos
May 10, 2007·Expert Review of Medical Devices·Vincenzo GuarinoLuigi Ambrosio
May 21, 2008·Journal of Biomedical Materials Research. Part a·Rodrigo OréficeAnthony Brennan

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Citations

Jun 8, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Stefan ZwingenbergerStuart B Goodman

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