Effect of long-term Intralipid administration in mice

Canadian Journal of Physiology and Pharmacology
T M Allen, L Murray

Abstract

Intralipid was administered intravenously to mice at a level of 2 g kg-1 day-1 for 23 days. No alterations in phagocytic index, liver or spleen size were observed in the chronically injected mice as compared with control mice that received saline injections. Tissue distribution of 0.45 micron multilamellar liposomes of egg phosphatidylcholine:cholesterol (2:1) was similar in mice that had been chronically injected with Intralipid to that in control mice. Mice chronically given the same total amount of phospholipid in the form of 0.2 micron liposomes of phosphatidylcholine:cholesterol (2:1) rather than as a lipid-triglyceride emulsion showed altered tissue distribution of entrapped label with decreased liver uptake and increased splenic uptake, which is indicative of reticuloendothelial blockade. Tissue distribution of [14C]dipalmitoylphosphatidylcholine Intralipid was compared with that of [14C]dipalmitoylphosphatidylcholine 0.2 micron MLV of phosphatidylcholine:cholesterol (2:1). Intralipid was taken up 2- to 3-fold less by liver and 5- to 10-fold less by spleen than liposomes. Blood levels of Intralipid were higher than those of liposomes. [14C]dipalmitoylphosphatidylcholine Intralipid was eliminated from the body at a faster...Continue Reading

Citations

Mar 20, 2002·The British Journal of Nutrition·D L WaitzbergRémy Meier
Dec 1, 1994·American Journal of Reproductive Immunology : AJRI·D A Clark
Oct 1, 1990·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S S DavisG Harper
Jun 29, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Dan L WaitzbergThiago Manzoni Jacintho
Feb 20, 2020·Scientific Reports·Yen-Ju ChenTsang-Wu Liu
Jan 1, 1996·Progress in Lipid Research·A C BachA Frey

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