Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis

The Journal of Laryngology and Otology
Aneta V PerićS Matković-Jožin

Abstract

Little is known about the effects of macrolides on the cytokines and chemokines that modulate the function of eosinophils in nasal polyposis. Twenty-two non-allergic and 18 allergic patients with nasal polyps were administered clarithromycin 500 mg/day (single oral dose) for eight weeks. We measured the nasal secretion levels of the T helper 2 (also known as Th2) cytokines interleukin 4, 5 and 6, the 'regulated on activation, normal T cell expressed and secreted' (also known as RANTES) chemokine, and the eosinophilic cationic protein, before and after treatment. After clarithromycin treatment, we found reduced levels of the 'regulated on activation, normal T cell expressed and secreted' chemokine in samples from both non-allergic and allergic patients (p < 0.05). Clarithromycin treatment decreased the levels of eosinophilic cationic protein only in non-allergic patients (p < 0.05), and decreased the level of interleukin 6 only in allergic patients (p < 0.05). Decreased levels of the 'regulated on activation, normal T cell expressed and secreted' chemokine were associated with a reduction in polyp size both in non-allergic and allergic patients. Clarithromycin has a strong anti-inflammatory effect in nasal polyposis, but has dif...Continue Reading

References

Jan 1, 1997·American Journal of Rhinology·M Yousef-Mian
Mar 10, 1998·Allergy·C BachertP van Cauwenberge
May 4, 1999·International Archives of Allergy and Immunology·C BachertP Van Cauwenberge
Sep 15, 1999·American Journal of Rhinology·M NonakaT Yagi
Dec 3, 1999·American Journal of Rhinology·T NorlanderP Stierna
May 24, 2000·The Annals of Otology, Rhinology, and Laryngology·C S RheeY Sakakura
Jul 11, 2000·American Journal of Rhinology·T YamadaH Saito
Jun 21, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Anders CervinSven Lindberg
Oct 3, 2002·Current Allergy and Asthma Reports·Claus BachertPaul van Cauwenberge
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Ruby Pawankar
Jul 24, 2003·Acta Oto-laryngologica·Harumi SuzakiTadashi Hisamitsu
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Anne TsicopoulosBenoît Wallaert
Apr 25, 2007·Acta Oto-laryngologica·Guo-Kang FanHiroshi Takenaka
Jan 8, 2008·The Journal of Laryngology and Otology·S LoA W McCombe
Dec 17, 2008·Clinical Physiology and Functional Imaging·Anders CervinLennart Greiff
Jan 20, 2011·American Journal of Rhinology & Allergy·Hyo-Hyun ParkHeung-Man Lee

❮ Previous
Next ❯

Citations

Jan 17, 2014·Current Allergy and Asthma Reports·Anders Cervin, Ben Wallwork
Feb 3, 2016·International Forum of Allergy & Rhinology·Cveta Špadijer-MirkovićDanilo Vojvodić
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Dec 19, 2015·International Forum of Allergy & Rhinology·Aleksandar PerićDanilo Vojvodić
Nov 26, 2015·Brazilian Journal of Otorhinolaryngology·Isamara Simas de OliveiraRoberto Eustáquio Santos Guimarães
Apr 25, 2015·International Forum of Allergy & Rhinology·Allen LamBenjamin S Bleier
Oct 15, 2014·The Journal of Allergy and Clinical Immunology·Mahboobeh MahdaviniaRobert P Schleimer
Jun 8, 2017·The Annals of Otology, Rhinology, and Laryngology·Cveta Špadijer MirkovićDanilo Vojvodić
Oct 16, 2014·The Annals of Otology, Rhinology, and Laryngology·Aleksandar PerićCveta Spadijer-Mirković
Mar 30, 2018·Frontiers in Immunology·Petra ZimmermannNicole Ritz
Jul 29, 2016·Allergy & Rhinology·Isamara Simas de OliveiraRoberto Eustáquio Santos Guimarães
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
A PerićO Miljanović
Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
A PerićO Miljanović
Plastic and Reconstructive Surgery
Dror AizenbudStephen A Schendel
© 2021 Meta ULC. All rights reserved