Effect of long-term maternal smoking on the offspring's lung health

American Journal of Physiology. Lung Cellular and Molecular Physiology
Surpon SukjamnongBrian Oliver

Abstract

Maternal smoking during pregnancy contributes to long-term health problems in offspring, especially respiratory disorders that can manifest in either childhood or adulthood. Receptors for advanced glycation end products (RAGE) are multiligand receptors abundantly localized in the lung, capable of responding to by-products of reactive oxygen species and proinflammatory responses. RAGE signaling is a key regulator of inflammation in cigarette smoking-related pulmonary diseases. However, the impact of maternal cigarette smoke exposure on lung RAGE signaling in the offspring is unclear. This study aims to investigate the effect of maternal cigarette smoke exposure (SE), as well as mitochondria-targeted antioxidant [mitoquinone mesylate (MitoQ)] treatment, during pregnancy on the RAGE-mediated signaling pathway in the lung of male offspring. Female Balb/c mice (8 wk) were divided into a sham group (exposed to air), an SE group (exposed to cigarette smoke), and an SE + MQ group (exposed to cigarette smoke with MitoQ supplement from mating). The lungs from male offspring were collected at 13 wk. RAGE and its downstream signaling, including nuclear factor-κB and mitogen-activated protein kinase family consisting of extracellular signal...Continue Reading

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Citations

May 16, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nagarjuna R CheemarlaAntonieta Guerrero-Plata
Sep 27, 2019·Clinical and Experimental Pharmacology & Physiology·Yik L ChanHui Chen
Apr 3, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Claudio Nardiello, Rory E Morty
Nov 18, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rory E Morty
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Baoming WangBrian G Oliver
Mar 2, 2018·American Journal of Respiratory Cell and Molecular Biology·Ross Vlahos
May 15, 2021·Environment International·Xiaotong JiNan Sang
Sep 30, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qianghu TangZhen Zou

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Methods Mentioned

BETA
Protein assay
PCR
lavage

Software Mentioned

Graphpad
ImageJ
Prism

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