Effect of long-term tamoxifen therapy on cancellous bone remodeling and structure in women with breast cancer

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
C D WrightJ E Compston

Abstract

The effects of long-term tamoxifen therapy on bone remodeling were studied in 41 women with breast cancer, 22 treated with tamoxifen for a minimum of 15 months (mean 33) and 19 untreated. Transiliac crest bone biopsies were obtained and a comprehensive histomorphometric analysis performed using a semiautomatic image analysis system. There were no statistically significant differences between the two groups in bone area, osteoid perimeter and area, or osteoid width. Mineral appositional rate, adjusted appositional rate, and mineralization lag time were also similar in the two groups; however, tissue-based bone formation rate was significantly lower in the tamoxifen-treated women (p = 0.05) and the remodeling period significantly longer (p < 0.05). Mean and maximum resorption cavity depth and cavity area were significantly reduced in the tamoxifen-treated patients compared to the untreated patients (p < 0.01, p < 0.01, and p < 0.03, respectively). Calculated and directly measured indices of cancellous bone structure were similar in the two groups, although the data indicated a trend toward greater connectedness in the tamoxifen-treated group. These data indicate that tamoxifen does not exert an antiestrogenic effect on bone remod...Continue Reading

References

Mar 26, 1992·The New England Journal of Medicine·R R LoveD L DeMets
Jan 1, 1991·Acta Endocrinologica·J H Tobias, T J Chambers
Oct 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J FoldesA M Parfitt
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T FornanderU Glas
Nov 1, 1989·Bone and Mineral·S FeldmannR Ziegler
Aug 1, 1989·British Journal of Cancer·I S FentimanI Fogelman
Oct 1, 1988·British Journal of Cancer·P F BruningW J Nooyen
Apr 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R R ReckerS Hinders
Dec 1, 1988·Breast Cancer Research and Treatment·G BertelliR Rosso
Oct 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R T TurnerN H Bell
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Oct 1, 1987·Breast Cancer Research and Treatment·V C JordanJ U Lindgren
May 12, 1973·British Medical Journal·J M AitkenC F Speirs
Jan 1, 1981·Calcified Tissue International·A J Darby, P J Meunier
Jan 1, 1982·Metabolic Bone Disease & Related Research·S VediJ R Tighe
Feb 13, 1993·BMJ : British Medical Journal·C D WrightJ E Compston

❮ Previous
Next ❯

Citations

Oct 1, 1995·Bone·G L Evans, R T Turner
Feb 19, 2000·Hematology/oncology Clinics of North America·S E Minton
Feb 5, 2009·Critical Reviews in Eukaryotic Gene Expression·Sue A Brown, Theresa A Guise
May 21, 2010·Arquivos brasileiros de endocrinologia e metabologia·Carolina A Moreira Kulak, David W Dempster
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·S G Nayfield
Jan 1, 1996·Obstetrical & Gynecological Survey·V L Baker, R B Jaffe
Jan 1, 1996·Breast Cancer Research and Treatment·J A Kalef-EzraD Glaros
Jan 12, 2001·Physiological Reviews·J E Compston
Jul 13, 2000·Obstetrical & Gynecological Survey·V L BakerR B Jaffe
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Susan M OttPaul Lips
Jun 16, 1999·Endocrine Reviews·F Cosman, R Lindsay
Nov 23, 2006·Arquivos brasileiros de endocrinologia e metabologia·Adolfo Diez-Perez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.