Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats

Environmental Toxicology and Pharmacology
Renata B KostogrysKinga Topolska

Abstract

The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soybean oil, 20% protein), WD (21% of butter, 20% protein), and LCHP (21% of butter and 52.4% protein) diet. The LCHP diet significantly decreased the body weight of the rats. Diet consumption was differentiated among groups, however significant changes were observed since third week of the experiment duration. Rats fed LCHP diet ate significantly less (25.2g/animal/day) than those from Control (30.2g/animal/day) and WD (27.8 g/animal/day) groups. Additionally, food efficiency ratio (FER) tended to decrease in LCHP fed rats. Serum homocysteine concentration significantly decreased in rats fed WD and LCHP diets. Liver weights were significantly higher in rats fed WD and LCHP diets. At the end of the experiment (2 months) the triacylglycerol (TAG) was significantly decreased in animals fed LCHP compared to WD. qRT-PCR showed that SCD-1 and FAS were decreased in LCHP fed rats, but WD diet increased expression of lipid me...Continue Reading

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Citations

May 12, 2016·Experimental Gerontology·Inga KadishThomas van Groen
Jul 31, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Junko SatoHirotaka Watada
Oct 26, 2018·Bioscience, Biotechnology, and Biochemistry·Kazuhiko HigashidaNaoya Nakai
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Dec 31, 2019·International Journal of Endocrinology·Xiaoshuai ZhangZhiwen Lai

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