Effect of low-dosage recombinant human growth hormone therapy on pulmonary function in hypopituitary patients with adult-onset growth hormone deficiency

Journal of Endocrinological Investigation
I MeineriM Giusti

Abstract

An impairment of the pulmonary function has been described in adult patients with childhood-onset growth hormone deficiency (GHD). We examined forced vital capacity (FVC), forced expiratory volume (FEV1), total lung capacity (TLC), functional residual capacity (FRC), residual volume (VR) and the index of inspiratory strength, middle tidal volume and tidal inspiratory time ratio (TV/I), in 29 patients with adult-onset GHD. Data were compared with those obtained in 46 healthy control subjects. Only the FEV1/FVC ratio was statistically different (p = 0.04) between the two groups of subjects. In a group of 15 GHD patients low dosages (0.5-1 IU/day s.c., bedtime) of recombinant human GH (rh-GH; n. = 8 subjects) or placebo (n. = 7) were given at random for a 6-month period. A significant increase in IGF-I levels was noted in the rh-GH-treated group (p = 0.04) but not in the placebo group. After the 6-month period no statistically significant changes in pulmonary function were found between the rh-GH-treated and placebo-treated GHD patients. This study shows that adult-onset GHD patients suffer from minimal impairment of pulmonary function. Low rh-GH dosages able to induce an increase in IGF-I levels do not improve pulmonary function....Continue Reading

References

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Citations

Dec 12, 2002·Chest·Tarja Saaresranta, Olli Polo
Jul 27, 2004·The Journal of Burn Care & Rehabilitation·Oscar E SumanDavid N Herndon
Nov 26, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Michael R GrahamJulien S Baker
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Harpal S RandevaStephen M Shalet

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