PMID: 6971829Feb 1, 1981Paper

Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: radiation damage in a mesenchymal system in vivo

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
J V Neal, C S Potten

Abstract

The effect of low dose ionizing radiation from a variety of sources on the murine small intestinal and colonic pericryptal fibroblast sheath (PCFS) has been investigated. Ultrastructural and light microscopic changes seen within 3 hours after radiation resembles the mode of cell death known as apoptosis. The apoptotic index (AI) was shown to rise steadily for 4 hours after irradiation, and then to return to control levels by 10 hours. 137Cs gamma-irradiation over a range of doses from 0-803 cGy caused an increase in AI from control values of 1-2 per cent to a plateau level of approximately 8.5 per cent for doses above 40 cGy. Investigation of the response of the PCFS to doses of 137Cs and 60Co gamma-irradiation and X-irradiation below 40 cGy demonstrated a steady increase with dose in AI. The survival curve for the radiosensitive subpopulation susceptible to death through apoptosis as a consequence of exposure to non-acute doses of radiation has a D0 of 10.6 cGy and an extrapolation number of 2.3.

References

Jan 1, 1969·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C W Gilbert
Apr 1, 1969·The Journal of Cell Biology·W D Troughton, J S Trier
Nov 1, 1954·American Journal of Clinical Pathology·S A BENCOSME

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Citations

Apr 25, 2007·Journal of Toxicology and Environmental Health. Part a·I DublineauP Gourmelon
Dec 1, 1990·International Journal of Radiation Biology·C S Potten
Sep 6, 2007·Journal of Radiation Research·Tetsuo Nakajima

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis