PMID: 9436565Jan 22, 1998Paper

Effect of low-dose positive inotropic drugs on human internal mammary artery flow

The Annals of Thoracic Surgery
J L CracowskiD Blin

Abstract

Dobutamine (a beta-receptor agonist), enoximone (a type III selective phosphodiesterase inhibitor), and epinephrine (an alpha- and beta-mimetic) frequently are used in the perioperative management of patients undergoing coronary artery bypass grafting. We performed a double-blind clinical study to compare the effects on internal mammary artery free flow of low doses of these three positive inotropic drugs. Thirty patients in whom the left internal mammary artery was used for coronary artery bypass grafting were randomized into three groups. Internal mammary artery free flow and hemodynamic measurements were evaluated before and 10 minutes after the intravenous infusion of dobutamine (3 microg x kg(-1) x min(-1)), enoximone (200 microg/kg), or epinephrine (0.05 microg x kg(-1) x min(-1)). A significant increase in free flow occurred only in the dobutamine group (33 +/- 7.5 and 42.2 +/- 7.9 mL/min before and after drug infusion, respectively; p = 0.013). Comparison of the increase in flow between the groups, however, showed no difference. These drugs, at doses designed to produce a positive inotropic effect, caused little increase in the free flow of the internal mammary artery. The use of dobutamine, enoximone, and epinephrine a...Continue Reading

References

Nov 1, 1991·The Journal of Thoracic and Cardiovascular Surgery·J A DiNardoR M Weintraub
Apr 1, 1989·The Annals of Thoracic Surgery·L K von SegesserM Turina
Aug 1, 1987·The Annals of Thoracic Surgery·M R SarabuG E Reed
Jan 1, 1982·The Annals of Thoracic Surgery·N W SalomonJ G Copeland
Sep 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·E DregelidE Svendsen
Feb 1, 1995·Journal of Pharmaceutical Sciences·S MoritaY Koike
Jan 25, 1996·The New England Journal of Medicine·A CameronH V Schaff

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Citations

Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Michael GilliesBrian Buxton
Sep 15, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Francesco OnoratiMaurizio Cotrufo
Jun 4, 1999·The Annals of Thoracic Surgery·O ChavanonD Blin
Oct 8, 2011·Medical Physics·Alonso Ramirez-ManzanaresJames C Gee
Nov 5, 1999·Journal of Cardiovascular Pharmacology·J L CracowskiP Devillier

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