PMID: 9416786Jan 7, 1998Paper

Effect of low-dose radiation on mouse dermal tissue using wound strength as an endpoint

International Journal of Radiation Biology
V VegesnaH R Withers

Abstract

To investigate the existence of enhanced sensitivity of dermal tissue to low radiation doses in the range of 0.1 Gy to 4 Gy/fraction. Top-up technique of giving higher radiation doses to skin alone from 150 kVp X-rays followed by fractionated experimental doses to total body from 137Cs were given to C3H mice. Full-depth incisions were made and the tensile strength of skin from 14 day wounds were measured as a response of dermal tissue to radiation. There was no evidence of enhanced radiosensitivity to doses as low as 0.1 Gy. The data were better fitted by a nonparametric method that predicted the shape of survival curve better than an induced-repair model. Dermal tissue like spinal cord has a low sensitive fraction of cells, unlike jejunum, kidney or lung that showed sensitivity at these doses. Tissue kinetics play an important role in the use of low dose fractions to avoid injury to normal tissues.

References

Apr 1, 1994·International Journal of Radiation Biology·B SinghM C Joiner
Jan 1, 1993·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·M C JoinerH Johns
Jul 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C S WongR P Hill

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Citations

Feb 6, 2010·Computer Methods and Programs in Biomedicine·Douglas L VizardWilliam E McLaughlin
Mar 31, 2007·Seminars in Radiation Oncology·James BrushWilliam H McBride
Aug 29, 2020·Radiation Research·Andrea L DiCarloCarmen I Rios
Aug 29, 2020·Radiation Research·Carmen I RiosLibero Marzella

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