Abstract
Angiotensin-converting enzyme (ACE) inhibitors can improve cardiac function independent of their blood pressure (BP)-lowering actions. We investigated the effect of chronic subantihypertensive ACE inhibitor treatment on functional and biochemical cardiac parameters in stroke-prone spontaneously hypertensive rats (SHRSP). Animals were treated in utero and subsequently to age 20 weeks with the ACE inhibitor perindopril (0.01 mg/kg/day). The contribution of endogenous bradykinin (BK) potentiation to the actions of the ACE inhibitor was assessed by cotreatment with the BK beta 2-receptor antagonist Hoe 140 (500 micrograms/kg/day subcutaneously, s.c.) from age 6 to 20 weeks and by measurement of myocardial prostacyclin and cyclic GMP concentrations. Chronic low-dose perindopril treatment had no effect on development of hypertension and left ventricular hypertrophy (LVH), but perindopril improved cardiac function, as demonstrated by increased LV pressure (LVP) (19.4%) and LVdp/dtmax (27.8%) but no change in heart rate (HR). The activities of lactate dehydrogenase (LDH) and creatine kinase (CK) as well as lactate concentrations in the coronary venous effluent were reduced by 39.3, 50, and 60.6%, respectively. Myocardial tissue concent...Continue Reading
Citations
Aug 21, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Ashraf TayeOmar M M Mohafez
Aug 4, 1997·The American Journal of Cardiology·Y C ZhuT Unger
May 4, 1999·European Journal of Pharmacology·E A KalkmanR G Schoemaker
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Christiane PeesPeter Gohlke
Jul 8, 2000·Kidney International·K AmannE Ritz
Jul 17, 2008·Seminars in Dialysis·Marie-Luise Gross, Eberhard Ritz
Jul 13, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuhisa KanematsuToshiaki Tamaki
Sep 21, 2013·Clinical and Experimental Hypertension : CHE·Bhoomika M Patel, Shraddha V Bhadada
Mar 18, 2000·Hypertension·S KimH Iwao
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·E L BlezerJ A Joles
Sep 1, 1996·Hypertension·P GohlkeT Unger
Nov 22, 1997·Hypertension·H YuM P Printz
Feb 7, 1998·Hypertension·P GohlkeT Unger
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S KimH Iwao
Oct 21, 2000·Hypertension·Y TakedaH Mabuchi
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca H RitchieG J Dusting
May 16, 2002·Journal of Hypertension·Peter Gohlke
Jun 2, 2012·Human & Experimental Toxicology·B M PatelS V Bhadada
Feb 20, 1998·Japanese Journal of Pharmacology·K ItoT Unger