Effect of low-dose treatment with perindopril on cardiac function in stroke-prone spontaneously hypertensive rats: role of bradykinin

Journal of Cardiovascular Pharmacology
P GohlkeT Unger

Abstract

Angiotensin-converting enzyme (ACE) inhibitors can improve cardiac function independent of their blood pressure (BP)-lowering actions. We investigated the effect of chronic subantihypertensive ACE inhibitor treatment on functional and biochemical cardiac parameters in stroke-prone spontaneously hypertensive rats (SHRSP). Animals were treated in utero and subsequently to age 20 weeks with the ACE inhibitor perindopril (0.01 mg/kg/day). The contribution of endogenous bradykinin (BK) potentiation to the actions of the ACE inhibitor was assessed by cotreatment with the BK beta 2-receptor antagonist Hoe 140 (500 micrograms/kg/day subcutaneously, s.c.) from age 6 to 20 weeks and by measurement of myocardial prostacyclin and cyclic GMP concentrations. Chronic low-dose perindopril treatment had no effect on development of hypertension and left ventricular hypertrophy (LVH), but perindopril improved cardiac function, as demonstrated by increased LV pressure (LVP) (19.4%) and LVdp/dtmax (27.8%) but no change in heart rate (HR). The activities of lactate dehydrogenase (LDH) and creatine kinase (CK) as well as lactate concentrations in the coronary venous effluent were reduced by 39.3, 50, and 60.6%, respectively. Myocardial tissue concent...Continue Reading

Citations

Aug 21, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Ashraf TayeOmar M M Mohafez
May 4, 1999·European Journal of Pharmacology·E A KalkmanR G Schoemaker
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Christiane PeesPeter Gohlke
Jul 17, 2008·Seminars in Dialysis·Marie-Luise Gross, Eberhard Ritz
Jul 13, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuhisa KanematsuToshiaki Tamaki
Sep 21, 2013·Clinical and Experimental Hypertension : CHE·Bhoomika M Patel, Shraddha V Bhadada
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·E L BlezerJ A Joles
Oct 21, 2000·Hypertension·Y TakedaH Mabuchi
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca H RitchieG J Dusting
Jun 2, 2012·Human & Experimental Toxicology·B M PatelS V Bhadada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.