Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model.

Cancer Research
Naoko KobayashiW J Aronson

Abstract

This study evaluated the effect of dietary fat on prostate cancer development by using the Hi-Myc mouse transgenic prostate cancer model. Hi-Myc mice develop murine prostatic intraepithelial neoplasia (mPIN) as early as 2 to 4 weeks and invasive adenocarcinoma between 6 and 9 months due to the overexpression of human c-Myc in the mouse prostate. Three-week-old male Hi-Myc mice were placed on high-fat (HF; 42% Kcal) or low-fat (LF; 12% Kcal) diets, and equal caloric intake was maintained until euthanasia at 7 months. The number of mice that developed invasive adenocarcinoma at 7 months was 27% less in the LF diet group (12/28) compared with the HF diet group (23/33, P < 0.05). Epithelial cells in mPIN lesions in the LF group had a significantly lower proliferative index compared with epithelial cells in the HF group (21.7% versus 28.9%, P < 0.05). During the mPIN phase of carcinogenesis (4 months), the LF group had higher serum insulin-like growth factor (IGF) binding protein-1 levels (21.0 +/- 8.9 ng/mL versus 3.2 +/- 0.8 ng/mL, P < 0.05) relative to the HF group. Akt (Ser(473)) phosphorylation, Akt kinase activity, and phosphorylation of downstream targets of Akt in prostates were significantly reduced in the LF diet group com...Continue Reading

References

Oct 4, 1995·Journal of the National Cancer Institute·Y WangW D Heston
Oct 6, 1993·Journal of the National Cancer Institute·E GiovannucciW C Willett
Dec 16, 1997·International Journal of Cancer. Journal International Du Cancer·M B VeierødD S Thelle
Jun 24, 1998·Journal of the National Cancer Institute·A WolkD Trichopoulos
Jun 23, 1999·Oncogene·G C Prendergast
Jun 23, 1999·Oncogene·C E NesbitE V Prochownik
Sep 21, 2000·Journal of the National Cancer Institute·H Yu, T Rohan
Aug 2, 2002·Cancer Cell·Shivapriya RamaswamyWilliam R Sellers
Oct 23, 2002·Molecular and Cellular Biology·Marc SchmidtRené H Medema
Apr 15, 2003·The Prostate·Paula J Kaplan-LefkoNorman M Greenberg
Jun 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pradip K MajumderWilliam R Sellers
Oct 3, 2003·Cancer Cell·Katharine Ellwood-YenCharles L Sawyers
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert K NamMichael Pollak
Aug 25, 2005·Gut·D Wang, R N Dubois
Sep 1, 2005·Prostate Cancer and Prostatic Diseases·G A SonnM S Litwin
Nov 17, 2005·Oncogene·Pradip K Majumder, William R Sellers
Jun 17, 2006·Genes & Development·Mei-Ling ChenNissim Hay
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoko KobayashiWilliam J Aronson
Mar 22, 2007·British Journal of Cancer·C E S ComstockK E Knudsen
Jul 4, 2007·The Journal of Clinical Investigation·Isabelle M BerquinYong Q Chen
Sep 4, 2007·Cancer Metastasis Reviews·Man-Tzu WangDaotai Nie

❮ Previous
Next ❯

Citations

Aug 1, 1992·Mechanisms of Development·G L EngelmannF W Ruscetti
Oct 31, 1991·Biochemical and Biophysical Research Communications·A FrazerR G Russell
Dec 17, 2011·Nutrition and Cancer·Ajit Vikram, Gopabandhu Jena
Sep 17, 2010·Genes & Development·Michael M Shen, Cory Abate-Shen
May 9, 2012·Molecular Cancer Therapeutics·Ramdev KonijetiWilliam J Aronson
Aug 19, 2010·Cancer Prevention Research·Elizabeth M MaskoStephen J Freedland
May 18, 2012·Endocrine-related Cancer·Dara Hope Cohen, Derek LeRoith
Sep 10, 2011·The Journal of Endocrinology·Ashley GrayColette Galet
Nov 6, 2013·Annual Review of Medicine·Goutham VemanaStephen J Freedland
Nov 30, 2010·Journal of Biomedicine & Biotechnology·Young S Kim, John A Milner
Dec 24, 2014·Nutrients·Katie M Di Sebastiano, Marina Mourtzakis
Feb 11, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marcel CetindisMartin Grimm
Dec 12, 2012·European Urology·Elizabeth M MaskoStephen J Freedland
Apr 17, 2012·Prostaglandins & Other Lipid Mediators·Janel Suburu, Yong Q Chen
Nov 29, 2011·European Urology·Cosimo De NunzioJ Kellogg Parsons
Jun 25, 2010·Biochemical and Biophysical Research Communications·Min HouVasundara Venkateswaran
Aug 6, 2010·The Prostate·Ramdev KonijetiWilliam J Aronson
Dec 23, 2014·Oncogene·D P LabbéM Brown
Nov 20, 2010·The American Journal of Pathology·Gemma LlaveriasPhilippe G Frank
Jan 13, 2015·BMC Medicine·Pao-Hwa LinStephen J Freedland
Jun 29, 2016·Prostate Cancer and Prostatic Diseases·J L KiwataC M Dieli-Conwright
Jan 18, 2017·Nutrition and Cancer·Wissam Zam, Aziz Khadour
Dec 6, 2017·Prostate Cancer and Prostatic Diseases·Susanne M HenningWilliam J Aronson
Jul 22, 2010·Nature Reviews. Urology·Vasundara Venkateswaran, Laurence H Klotz
Sep 17, 2015·Endocrine-related Cancer·Emma H Allott, Stephen D Hursting
Dec 13, 2017·Cold Spring Harbor Perspectives in Medicine·Giorgia Zadra, Massimo Loda
Feb 27, 2019·International Journal of Cancer. Journal International Du Cancer·Aurora Perez-CornagoTimothy J Key
Jul 3, 2019·The Journal of Clinical Investigation·Yihai Cao
May 6, 2019·Journal of Clinical Medicine·Shintaro NaritaTomonori Habuchi
Jun 18, 2020·Nature Reviews. Cancer·Johann S de BonoAndrea Alimonti

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