PMID: 11316121Apr 24, 2001Paper

Effect of low-intensity warfarin therapy on left atrial thrombus resolution in patients with nonvalvular atrial fibrillation: a transesophageal echocardiographic study

Japanese Circulation Journal
M KimuraM Matsuzaki

Abstract

The presence of left atrial thrombus (LAT) is associated with an increased risk of embolic stroke. However, it has yet to be established definitively whether low-intensity warfarin therapy (INR: 1.5-2.0) can prevent LAT formation in patients with nonvalvular atrial fibrillation (NVAF). The present study analyzed the clinical and transesophageal echocardiography (TEE) features of 123 such patients to identify risk factors for LAT formation and the efficacy of prophylactic low-intensity warfarin therapy. Left atrial thrombi were found in 35 patients (28%) in whom systemic hypertension (49% vs 23%; p<0.01) and ischemic heart disease (17% vs 3%; p<0.01) were more frequent. Left ventricular ejection fraction (54+/-14% vs 60+/-11%; p<0.05), left ventricular end-diastolic dimension (51+/-7 mm vs 48+/-5 mm; p<0.05), spontaneous echo contrast (2.2+/-0.7 vs 1.4+/-0.9; p<0.01), left atrial diameter (50+/-6 mm vs 43+/-7 mm; p<0.01), left atrial appendage blood velocity (22.3+/-8.7 cm/s vs 37.2+/-21.5 cm/s; p<0.01) and the incidence of left ventricular hypertrophy (37% vs 15%; p<0.01) were also significantly different between the groups. Fourteen patients received continuous warfarin therapy (target INR: 1.5-2.0) and on the follow-up TEE st...Continue Reading

References

Oct 1, 1977·The American Journal of Cardiology·R C HintonC M Fisher
Dec 12, 1992·BMJ : British Medical Journal·G D Lowe
Aug 1, 1991·Journal of the American College of Cardiology·I W BlackW F Walsh
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Nov 1, 1991·Journal of the American College of Cardiology·A C PearsonA J Labovitz
Jun 1, 1988·Journal of the American College of Cardiology·W G DanielP R Lichtlen
Aug 1, 1988·Stroke; a Journal of Cerebral Circulation·J L Halperin, R G Hart
Jan 1, 1986·Journal of the American College of Cardiology·W AschenbergW Bleifeld
Jan 1, 1981·Investigative Radiology·B SigelV Capek
Sep 1, 1994·Journal of the American College of Cardiology·D Y LeungW F Walsh

❮ Previous
Next ❯

Citations

Dec 24, 2013·Thrombosis Journal·Tohru KawakamiHiroki Ishihara
Jul 24, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Katsuhiko MatsuyamaTakehiko Matsuo
Oct 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Xiaoyan ZhouChuwa Tei
Jan 10, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Tatsuyoshi NarumiyaKatsuo Kanmatsuse
Feb 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Yukihiko AbeYukio Maruyama
Mar 27, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Fumihiko TakeuchiNorihiro Kato
Aug 8, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Takahiro NishidaRyuji Tominaga
Nov 6, 2018·Cardiovascular Research·Ahsan A Khan, Gregory Y H Lip
May 19, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paolo VerdecchiaGiuseppe Di Pasquale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.