PMID: 8944673Nov 11, 1996Paper

Effect of low-level basal plus marked "pulsatile" hyperglycemia on insulin secretion in fetal sheep

The American Journal of Physiology
T D CarverW W Hay

Abstract

We compared fetal glucose- and arginine-stimulated insulin secretion (delta I, pM) among four groups of pregnant sheep after 10-11 days of different maternal glycemic patterns: 1) control, euglycemic; 2) low-level basal plus "pulsatile" hyperglycemic (PHG group); 3) markedly hyperglycemic (HG) group); 4) markedly hypoglycemic (LG group). Mean delta I during a hyperglycemic clamp was greatest in the PHG group (190 +/- 28 pM, P < 0.01) and least in the HG (64 +/- 13 pM, P < 0.05) and LG groups (68 +/- 15 pM, P < 0.05) compared with the control group (126 +/- 18 pM). After an arginine bolus, insulin concentration was greater in the PHG group at two of four sampling times over 30 min compared with the control group and at all times compared with the HG and LG groups. The trend in mean delta I over the postarginine sampling period (PHG 1,092 +/- 114 pM; control 921 +/- 86 pM; HG897 +/- 117 pM; LG831 +/- 57 pM) was in the same direction as for glucose and was significant (P < 0.05). Thus glucose-stimulated fetal insulin secretion is regulated by the duration and pattern, as well as the magnitude, of maternal and fetal hyperglycemia; this regulation may also extend to insulin-secretion capacity.

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Citations

Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P J ThureenW W Hay
Feb 15, 2001·International Journal of Epidemiology·J E Harding
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·U G DasS U Devaskar
Feb 5, 2009·American Journal of Physiology. Endocrinology and Metabolism·Sean W LimesandWilliam W Hay
Mar 30, 2006·American Journal of Physiology. Endocrinology and Metabolism·Paul J RozanceWilliam W Hay
Feb 19, 2016·Physiology·Sherin U Devaskar, Alison Chu
Jan 26, 2002·British Medical Bulletin·A L Fowden, D J Hill
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Feb 27, 2020·American Journal of Physiology. Endocrinology and Metabolism·Ana-Mishel SpiroskiFrank Harry Bloomfield
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·P J ThureenW W Hay
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B T JacksonW R Cohen
Jul 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephen P FordMark J Nijland
Jul 6, 2018·Journal of Developmental Origins of Health and Disease·B H BoehmerP J Rozance

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