Effect of low-level laser treatment on cochlea hair-cell recovery after ototoxic hearing loss

Journal of Biomedical Optics
Chung-Ku RheeMyung-Whan Suh

Abstract

The primary cause of hearing loss includes damage to cochlear hair cells. Low-level laser therapy (LLLT) has become a popular treatment for damaged nervous systems. Based on the idea that cochlea hair cells and neural cells are from same developmental origin, the effect of LLLT on hearing loss in animal models is evaluated. Hearing loss animal models were established, and the animals were irradiated by 830-nm diode laser once a day for 10 days. Power density of the laser treatment was 900 mW/cm(2), and the fluence was 162 to 194 J. The tympanic membrane was evaluated after LLLT. Thresholds of auditory brainstem responses were evaluated before treatment, after gentamicin, and after 10 days of LLLT. Quantitative scanning electron microscopic (SEM) observations were done by counting remaining hair cells. Tympanic membranes were intact at the end of the experiment. No adverse tissue reaction was found. On SEM images, LLLT significantly increased the number of hair cells in middle and basal turns. Hearing was significantly improved by laser irradiation. After LLLT treatment, both the hearing threshold and hair-cell count significantly improved.

Citations

Jan 8, 2016·Lasers in Medical Science·Tae-Hyun MoonMyung-Whan Suh
Oct 22, 2016·Neuroscience Letters·Min Young LeeJae Yun Jung
Aug 31, 2017·Journal of Biomedical Optics·Min Young LeeChung Ku Rhee
Aug 23, 2019·Journal of Biomedical Optics·Katharina SorgGentiana I Wenzel
Aug 29, 2019·Biomedical Engineering Letters·Jae-Hun LeeMin Young Lee
Aug 15, 2018·Lasers in Medical Science·So-Young ChangMin Young Lee

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