PMID: 7023249Aug 1, 1981Paper

Effect of low-level renal nerve stimulation on renin release from nonfiltering kidneys

The American Journal of Physiology
H HoldaasF Kiil

Abstract

The mechanism whereby renal nerves influence the renin-release response to aortic constriction was examined in a nonfiltering ureter-occluded kidney preparation in anesthetized dogs. The kidney was rendered nonfiltering by a combination of mannitol infusion and ureteral occlusion. Suprarenal aortic constriction reduced renal perfusion pressure to 61 +/- 7 mmHg and increased renin release from 16.7 +/- 4.1 to 26.1 +/- 6.0 U/min. At normal renal perfusion pressure, low-frequency renal nerve stimulation (0.25 Hz) increased renin release by 11.6 +/- 4.2 to 25.1 +/- 7.6 U/min. The effect of combined low-level renal nerve stimulation and aortic constriction on renin release was additive; renin release increased by 24.6 +/- 6.5 to 39.5 +/- 7.3 U/min. Propranolol or metoprolol, administered intrarenally at 2 microgram . min-1 . kg-1, abolished the renin-release response to low-level renal nerve stimulation at normal renal perfusion pressure. These data provide evidence that low-frequency renal nerve stimulation influences the renin-release response to reduction in renal perfusion pressure in a nonfiltering ureter-occluded kidney with an inoperative macula densa receptor mechanism. The neural effect on renin release at normal renal perf...Continue Reading

Citations

Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J BarrettS C Malpas
Oct 22, 2010·American Journal of Physiology. Renal Physiology·Sarah C ClaytonIrving H Zucker
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M L DraperJ C Rose
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter BieSøren Wamberg

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