Effect of lower esophageal sphincter tone and crural diaphragm contraction on distensibility of the gastroesophageal junction in humans

American Journal of Physiology. Gastrointestinal and Liver Physiology
Reza ShakerWalter J Hogan

Abstract

Previous studies of distensibility of the gastroesophageal junction (GEJ) in humans have not tried to distinguish between the effects of muscle action and passive elastic tissue properties of the GEJ. We studied 15 healthy subjects (ages 23-67 yr, 11 men/4 women) by using a catheter with a highly complaint bag positioned manometrically at the GEJ. The bag was distended with air at a rate of 20 ml/min while intrabag pressure was recorded. Distensions were performed during normal breathing, with breath held at maximum inspiration (MI) to activate the diaphragmatic crura, and with midesophageal balloon distension (BD) to relax the lower esophageal sphincter. In 10 subjects, distensions were performed after atropine injection (12 microg/kg iv). Pressure-volume curves and incremental distensibility values were calculated and compared among the different conditions. Both MI and BD significantly altered the slopes of the pressure-volume curves, whereas no effect was seen with atropine. Maximum distensibility was seen at the volume increment of 5-10 ml and was reduced with larger volumes. Distensibility measurements for the various test conditions tended to converge at the largest volume increment, suggesting that distensibility at thi...Continue Reading

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Citations

Jun 6, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michèle BoironNoël Huten
Jan 10, 2009·World Journal of Gastroenterology : WJG·Barry P McMahonHans Gregersen
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Jun 9, 2006·Current Opinion in Gastroenterology·Ibrahim Dogan, Ravinder K Mittal
Dec 13, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J L PuckettR K Mittal
Aug 20, 2020·Annals of the New York Academy of Sciences·John O ClarkeMarcelo F Vela
Apr 3, 2018·Journal of Neurogastroenterology and Motility·Hans Gregersen, Kar Man Lo
Sep 5, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Barry P McMahonHans Gregersen
May 24, 2006·World Journal of Gastroenterology : WJG·Barry P McMahonHans Gregersen
Jul 12, 2020·Current Gastroenterology Reports·Benson T Massey

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