PMID: 8945991Nov 1, 1996Paper

Effect of luminal angiotensin II and ANP on early and late cortical distal tubule HCO3- reabsorption

The American Journal of Physiology
M L Barreto-Chaves, Margarida Mello-Aires

Abstract

Bicarbonate reabsorption was evaluated by stationary microperfusion "in vivo" early distal (ED) and late distal (LD) segments of at kidney. Intratubular pH was recorded by double-barreled of H+ exchange resin/reference (1 M KCl) microelectrodes for the determination of HCO3- reabsorption. In the presence of angiotensin II (ANG II) (10(-12) M), a significant increase in HCO3- reabsorption was observed both in ED (from 0.930 +/- 0.060 to 2.64 +/- 0.210 nmol.cm-2.s-1 in luminally perfused tubules and from 0.850 +/- 0.040 to 2.03 +/- 0.210 nmol.cm-2.s-1 during capillary perfusion) and LD segments from 0.310 +/- 0.130 to 2.16 +/- 0.151 nmol.cm-2.s-1 during luminal perfusion and from 0.530 +/- 0.031 to 2.16 +/- 0.211 nmol.cm-2.s-1 with capillary perfusion). The addition of the AT1-receptor antagonist losartan (10(-6) M) to luminal perfusion blocked luminal ANG II-mediated stimulation in ED and LD segments. 5-(N,N-hexamethylene)amiloride (10(-4) M) added to luminal perfusion inhibited luminal ANG II-mediated stimulation in ED (by 81%) and LD (by 54%) segments. The addition of bafilomycin A1 (2 x 10(-7) M) to luminal perfusion does not affect luminal ANG II-mediated stimulation in ED segments but reduces it in LD segments (by 33%). Dur...Continue Reading

Citations

Apr 22, 2004·American Journal of Physiology. Renal Physiology·Nicolas LerollePascal Houillier
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Oct 29, 2000·American Journal of Physiology. Renal Physiology·M Oliveira-Souza, M De Mello-Aires
Mar 8, 2002·Hypertension·L Gabriel NavarHiroyuki Kobori
Feb 29, 2008·American Journal of Physiology. Renal Physiology·Veerendra K Madala HalagappaCarolyn M Ecelbarger
Mar 1, 2001·Journal of the Renin-angiotensin-aldosterone System : JRAAS·L Gabriel NavarAkira Nishiyama
May 3, 2013·American Journal of Physiology. Renal Physiology·Susan M Wall, Alan M Weinstein
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·L Gabriel Navar, Akira Nishiyama
Apr 22, 2004·American Journal of Physiology. Renal Physiology·V Matti VehaskariJennifer Manning
Jul 31, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken ImanishiKimio Tomita
Apr 28, 2005·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Mar 11, 2000·American Journal of Physiology. Renal Physiology·D Z LevineJ N Fryer
Apr 17, 2004·Kidney International·L Gabriel Navar
Jan 5, 2010·Journal of the American Society of Hypertension : JASH·Minolfa C Prieto-CarrasqueroL Gabriel Navar

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