Effect of luminance contrast on BOLD fMRI response in human primary visual areas

Journal of Neurophysiology
B G Goodyear, R S Menon

Abstract

In this study, we examined the effect of stimulus luminance contrast on blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging within human visual cortex (V1 and extrastriate). Between experiments, the calibrated luminance of a single red LED covering 2 degrees of the subject's visual field was changed relative to a constant background luminance. This stimulus provided a different foveal luminance contrast for each experiment. We used an echo planar imaging sequence to collect blood-oxygenation-sensitive images during and in the absence of the presented stimulus. Our results showed that within V1 there was an increase in the spatial extent of activation with increasing stimulus contrast, but no trend was seen within extrastriate. In both V1 and extrastriate, the local mean activation level for all activated image pixels remained constant with increasing luminance contrast. However, when we investigated activated pixels common to all luminance contrast levels, we found that there was an increase in the mean activation level within V1, but not within extrastriate. These results suggest that there is an increase in the activity of cells in V1 with increasing luminance contrast.

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Citations

Oct 12, 2000·Journal of Neurophysiology·B G GoodyearR S Menon
Oct 16, 2001·Journal of Neurophysiology·B T BackusD J Heeger
Apr 17, 2003·Experimental Brain Research·Sarah A KhanStefan Everling
Jan 1, 2017·Multisensory Research·Giles Hamilton-FletcherJamie Ward
Dec 12, 2019·Journal of Neurophysiology·Louis N Vinke, Sam Ling
Apr 3, 2008·Human Brain Mapping·Miika PihlajaSimo Vanni
Aug 31, 2002·Journal of Magnetic Resonance Imaging : JMRI·Feroze B MohamedJoseph I Tracy
Sep 15, 2005·Perceptual and Motor Skills·Kong-King Shieh, Mei-Hsiang Chen
May 4, 2004·Arquivos de neuro-psiquiatria·Murilo S MenesesMaria L A Vítola
May 31, 2012·Experimental Brain Research·Jeremy W MurphyEdmund C Lalor
Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S Menon, B G Goodyear
Apr 23, 2019·Psychological Science·Eugene L KwokJoel Pearson
Mar 23, 2012·Developmental Cognitive Neuroscience·Julia J HarrisDavid Attwell

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