PMID: 8970557Dec 1, 1996Paper

Effect of lung contusion on surfactant composition in multiple-trauma patients

The Journal of Trauma
M AufinkolkK P Schmit-Neuerburg

Abstract

The aim of this study was to investigate alterations of the surfactant system in multiple-trauma patients (MTP) with lung contusion and the influence of single- or multiple-organ dysfunction syndrome (OF/MOF) on the surfactant system. University hospital, trauma-intensive care unit. Prospective, nonrandomized study. MTP with an Injury Severity Score > 19 points have been recorded prospectively since 1992. Bronchoalveolar lavages were obtained daily either until day 14 or extubation. Three groups of MTP were compared: noL: MTP, no lung contusion (n = 14); LuCo-: MTP, lung contusion, no OF/MOF (n = 17); LuCo+: MTP, lung contusion, with OF/MOF (n = 10). Also, surfactant samples of 11 healthy volunteers (Con) were investigated and compared with MTP. All data were presented as mean +/- SEM. Statistical analysis were performed using programs of SPSS 6.0.1. (univariate ANOVA, Fisher's Exact Test, p < = 0.05). There were no differences in sex and age. Injury Severity Score was significantly impaired in group LuCo+ (44 +/- 4), compared with groups noL (31 +/- 3) and LuCo- (34 +/- 3). Group noL showed no statistical differences for lung function, total protein, and total phospholipid content of the bronchoalveolar lavage compared with gr...Continue Reading

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Citations

Jul 3, 2013·The American Journal of Emergency Medicine·David CouretPierre Michelet
Aug 11, 2006·Chest·Gino SoldatiNicolò G Silveri
Aug 26, 1998·The Journal of Trauma·C B MoomeyK G Proctor

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