Effect of lycopene on titanium implant osseointegration in ovariectomized rats

Journal of Orthopaedic Surgery and Research
Xiaojie LiMengsheng Xie

Abstract

Lycopene prevents bone loss in osteopenic models. However, the role of lycopene in the success rate of dental implants under osteopenic conditions remains unknown. The aim of this study was to evaluate whether lycopene prevents delayed implant osseointegration in an ovariectomized (OVX) rat model. Thirty female Sprague-Dawley rats were randomly divided into the following groups: OVX with vehicle (OVX group), OVX with lycopene (OVX + lycopene group) and sham-operated with vehicle (sham group). Twelve weeks after ovariectomy or sham operation, titanium implants were placed into the distal metaphysis of the bilateral femurs of each rat. These rats were subsequently gavaged with lycopene (50 mg/kg/day) or vehicle. After 12 weeks of gavage, all rats were sacrificed, and specimens were harvested. Sample osseointegration was evaluated by biomechanical testing, 3D micro-computed tomography (micro-CT) analysis and histomorphometric analysis. Compared with the OVX group, the OVX + lycopene group showed a 69.3% increase in the maximum push-out force (p < 0.01). Micro-CT data for the femurs in the OVX + lycopene group showed significantly higher bone volume, trabecular thickness and less trabecular space than did those in the OVX group. Th...Continue Reading

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Citations

Aug 1, 2020·Current Osteoporosis Reports·Kyle D AndersonRyan D Ross
Oct 1, 2020·International Journal of Molecular Sciences·Umani S WalallawitaJulian A Heyes
Jan 18, 2022·Journal of Periodontal Research·Natsumi SaitoTakanori Iwata

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