PMID: 8458762Feb 1, 1993Paper

Effect of lymph composition on an in vitro preparation of the alligator lizard cochlea

Hearing Research
D M FreemanT F Weiss

Abstract

The effects of different artificial lymphs on the cochlear duct of the alligator lizard were studied in an in vitro preparation. The duct was dissected and cemented to the glass floor of a chamber that had been filled with an artificial lymph. The vestibular membrane was removed and latex beads (1-5 microns in diameter) were allowed to settle on the endolymphatic surface of the duct. During perfusion with an artificial lymph solution, the positions of beads were measured and video images of the duct were obtained. Artificial lymphs were isosmotic and included artificial endolymph (AE), artificial perilymph (AP), Leibovitz's L-15 culture medium, an AE solution whose calcium concentration was the same as that of AP, and AE and AP solutions in which gluconate was substituted for chloride ions. Results obtained in AE were consistently different from those in other lymphs. The displacements of beads, the projected area of the papilla, the occurrence of blebs, and direct observation of cells in the duct all indicated that the tissue swelled in AE (with or without 2 mmol/l Ca) but showed no consistent shrinking or swelling in any of the other artificial lymphs. Thus for the solutions we used, the presence of both potassium and chlorid...Continue Reading

References

Aug 1, 1978·The Journal of Physiology·H Bracho, R Budelli
Nov 1, 1976·The American Journal of Anatomy·J B NadolT F Weiss
Sep 1, 1990·Hearing Research·D M Freeman, T F Weiss
Jan 1, 1986·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·A H GitterE Frömter
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Oct 1, 1979·Applied Optics·R O Cook, C W Hamm

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Citations

Jun 5, 2003·Hearing Research·Dennis M FreemanThomas F Weiss
Jan 10, 2012·The Journal of the Acoustical Society of America·Manuela Nowotny, Anthony W Gummer
May 15, 2003·The Journal of Comparative Neurology·Olga Ganeshina, Misha Vorobyev
Nov 10, 2006·Journal of Biomedical Optics·Stanley S Hong, Dennis M Freeman
Feb 28, 1998·Immunologic Research·Y Paterson
Sep 24, 2005·Journal of Neurophysiology·Jingbing Xue, E H Peterson

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