Effect of lysogeny on serum sensitivity.

Journal of Bacteriology
L H MuschelL S Baron

Abstract

When Escherichia coli K-12 was infected with lambda phage and mutants of lambda characterized by the production of temperature-sensitive repressors, the lysogenic bacteria were significantly more resistant to normal serum than the uninfected organisms. Infection of E. coli K-12 with a lambdoid phage, phi80, whose prophage attachment site is different from that of lambda, did not result in a detectable change in serum resistance. Similarly, infection with certain Pseudomonas and Shigella phages caused no detectable differences in serum resistance. Finally, the well-known conversion of the Salmonella anatum serotype to S. newington by E(15) phage indicated that, despite the relatively greater roughness of S. anatum, S. newington was more sensitive to normal serum than S. anatum. Thus, the effects of lysogeny on the sensitivity of bacteria to the bactericidal action of serum mediated by the complement system may be quite variable.

References

Oct 1, 1966·Journal of Bacteriology·L H Muschel, K Schmoker
Feb 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·L H MUSCHELE OSAWA
Mar 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·L H MUSCHEL

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